| Project/Area Number |
22700321
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | The Institute of Physical and Chemical Research (2011-2012)
Kyoto University (2010) |
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Principal Investigator |
NOMURA Masaki 独立行政法人理化学研究所, 細胞システムモデル化研究チーム, 研究員 (90552688)
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| Research Collaborator |
SAKURAI Yoshio 京都大学, 大学院・文学研究科, 教授 (60153962)
GOHARA Kazutoshi 北海道大学, 大学院・工学研究科, 教授 (40153746)
KUBOTA Yoshiyuki 生理学研究所, 大脳皮質機能研究系, 准教授 (90192567)
KIMURA Shuhei 鳥取大学, 大学院・工学研究科, 准教授
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 神経回路モデル / ベイズ推定 / 神経細胞モデル / ロルの法則 / 錐体細胞 / 抑制性シナプス / 数理モデル / シミュレーション / 培養神経細胞 / 同期活動 / バースト活動 / 神経回路網モデル / パラメータ推定 / ダイナミックベイズモデル / 必要条件 / 十分条件 |
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| Research Abstract |
I estimated a functional connectivity of neuronal network from burst like neuronal spike data recorded from cultured neurons. With using a dynamic Bayesian estimation algorithm, I obtained a network model the distribution of synaptic weights of which has a long tail. The obtained model could reproduce the burst like neuronal activities, which disappeared when the synaptic weights were shuffled. These results suggest that both the weight distribution and the network structure are important to induce the burst like neuronal activities.
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