Information processing principle inferred from cortical spike sequences

• Project/Area Number: 22700323
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Bioinformatics/Life informatics
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: TSUBO Yasuhiro 独立行政法人理化学研究所, 脳回路機能理論研究チーム, 研究員 (40384721)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 大脳皮質 / 局所回路 / 情報処理 / スパイク時系列 / 情報理論 / 運動野 / 神経細胞モデル / 確率過程 / ラット運動野

Research Abstract

Spike sequences observed from cerebral cortex neurons are highly irregular. We explored the principle of information processing in cortical neuronal system using irregular spike trains, by means of analyzing the power-law statistics of inter-spike intervals. We revised a conditional entropy minimization hypothesis that proposed in our previous study and proposed a "constrained maximization of firing-rate entropy" (CMFE) hypothesis. We further extended the CMFE theory to match more realistic situation of neural activities.

Research Products

• [Journal Article] Neural dynamics and information representation in microcircuits of motor cortex. (2013)
  • Author(s): Yasuhiro Tsubo, Yoshikazu Isomura, Tomoki Fukai
  • Journal Title: Frontiers in Neural Circuits Volume: 7 Pages: 1-10
  • DOI: 10.3389/fncir.2013.00085
  • Peer Reviewed
• [Journal Article] Passage-time coding with a timing kernel inferred from irregular cortical spike sequences. (2013)
  • Author(s): Yasuhiro Tsubo, Yoshikazu Isomura, Tomoki Fukai
  • Journal Title: Journal of Statistical Mechanics: Theory and Experiment Volume: 2013 Issue: 03 Pages: P03004-P03004
  • DOI: 10.1088/1742-5468/2013/03/p03004
  • Peer Reviewed
• [Journal Article] Optimal spike-based communication in excitable networks with strong-sparse and weak-dense links. (2012)
  • Author(s): Jun-Nosuke Teramae, Yasuhiro Tsubo, Tomoki Fukai
  • Journal Title: Scientific Reports Volume: 2 Issue: 1 Pages: 485-485
  • DOI: 10.1038/srep00485
  • Peer Reviewed
• [Journal Article] Power-law inter-spike interval distributions infer a conditional maximization of entropy in cortical neurons (2012)
  • Author(s): Tsubo Y, et al
  • Journal Title: PLoS Comput.Biol. Volume: 8 Issue: 4 Pages: e1002461-e1002461
  • DOI: 10.1371/journal.pcbi.1002461
  • Peer Reviewed
• [Journal Article] Power-law inter-spike interval distributions infer a conditional maximization of entropy in cortical neurons (2012)
  • Author(s): Yasuhiro Tsubo, et al
  • Journal Title: PLoS Computational Biology Volume: (In press)
  • Peer Reviewed
• [Journal Article] Javaによる活動電位のシミュレーション (2011)
  • Author(s): 坪泰宏, ら
  • Journal Title: 日本大学医学部一般教育研究紀要 Volume: 39 Pages: 13-31
• [Journal Article] Estimating time-varying input signals and ion channel states from a single voltage trace of a neuron (2011)
  • Author(s): Ryota Kobayashi, et al
  • Journal Title: Advances in Neural Information Processing Systems Volume: 24 Pages: 181-181
  • Peer Reviewed
• [Journal Article] Bayesian estimation of phase response curves (2010)
  • Author(s): Ken Nakae, et al.
  • Journal Title: Neural Networks Volume: 23 Pages: 752-763
  • Peer Reviewed
• [Presentation] 経過時間コーディングにおける発火率エントロピー最大化 (2013)
  • Author(s): 坪 泰宏 ら
  • Organizer: 日本物理学会第68回年次大会
  • Place of Presentation: 広島大学東広島キャンパス
• [Presentation] Passage-time coding inferred from power-law cortical spike sequences. (2012)
  • Author(s): Yasuhiro Tsubo and Tomoki Fukai
  • Organizer: Neuroscience 2012, SFN 42nd Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Ernest N Morial Convention Center,New Orleans, USA
  • Year and Date: 2012-10-16
• [Presentation] Passage-time coding with optimized firing-rate kernel inferred from irregular cortical spike sequences. (2012)
  • Author(s): Yasuhiro Tsubo and Tomoki Fukai
  • Organizer: The 35th Annual meeting of the Japanese Neuroscience Society
  • Place of Presentation: Nagoya Congress Center,Nagoya, Aich
  • Year and Date: 2012-09-21
• [Presentation] Passage-time coding with optimized firing-rate kernel inferred from irregular cortical spike sequences (2012)
  • Author(s): Yasuhiro Tsubo et al.
  • Organizer: The 35th Annual meeting of the Japanese Neuroscience Society
  • Place of Presentation: Nagoya Congress Center
• [Presentation] 制約付エントロピー最大化に基づく脳型パルス間隔通信 (2012)
  • Author(s): 坪 泰宏 ら
  • Organizer: 電子情報通信学会NetSci/CCS研究会合同ワークショップ
  • Place of Presentation: 北海道大学
• [Presentation] Non-Gaussian fluctuation of macroscopic observable infers network topology of oscillators. (2011)
  • Author(s): Yasuhiro Tsubo and Tomoki Fukai
  • Organizer: The 21st Annual Conference of the Japanese Neural Network Society
  • Place of Presentation: OIST Seaside House,Onna, Okinawa
  • Year and Date: 2011-12-16
• [Presentation] Non-Gaussian fluctuation of macroscopic observable infers network topology of oscillators (2011)
  • Author(s): 坪泰宏, 深井朋樹
  • Organizer: 日本神経回路学会
  • Place of Presentation: OIST, (Onna, Okinawa)
  • Year and Date: 2011-12-16
• [Presentation] Lognormal sparse connectivity generates intrinsic noise optimal for information processing in cortical networks (2011)
  • Author(s): Jun-nosuke Teramae,Yasuhiro Tsubo and Tomoki Fukai
  • Organizer: The 34th Annual meeting of the Japanese Neuroscience Society
  • Place of Presentation: Pacifico Yokohama,Yokohama, Kanagawa
  • Year and Date: 2011-09-17
• [Presentation] シナプス結合の対数正規分布則は最適なノイズを生成し皮質の信号伝達を最適化する (2011)
  • Author(s): 寺前順之介, ら
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2011-09-17
• [Presentation] ラット運動野神経活動から示唆される運動タイミングに関連したバランスシナプス入力 (2011)
  • Author(s): 坪泰宏, ら
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2011-09-16
• [Presentation] Long-tailed statistics of corticocortical EPSPs : Origin and computational role of noise in cortical circuits (2011)
  • Author(s): Jun-nosuke Teramae, et al
  • Organizer: The 3rd International Conference on Cognitive Neurodynamics
  • Place of Presentation: Hilton Niseko Village, (Niseko, Hokkaido)
  • Year and Date: 2011-06-12
• [Presentation] Estimating time-varying input signals and ion channel states from a single voltage trace of a neuron. (2011)
  • Author(s): Ryota Kobayashi,Yasuhiro Tsubo,Petr Lansky and Shigeru Shinomoto
  • Organizer: Advances in Neural Information Processing Systems (NIPS 2011)
  • Place of Presentation: Granada Congress and Exhibition Centre,Granada, Spain
• [Presentation] 神経細胞の動的膜特性の多様性 (2010)
  • Author(s): 坪泰宏
  • Organizer: 統計数理研究所「神経科学と統計科学の対話」研究会
  • Place of Presentation: 統計数理研究所(東京都立川市)
  • Year and Date: 2010-12-19
• [Presentation] 不規則発火時系列に対する条件付エントロピー最小化原理 (2010)
  • Author(s): 坪泰宏, ら
  • Organizer: 第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会合同大会
  • Place of Presentation: 神戸コンベンションセンター(神戸市)
  • Year and Date: 2010-09-04
• [Presentation] 不規則神経発火時系列に対する条件付エントロピー最小化原理 (2010)
  • Author(s): 坪泰宏
  • Organizer: 統計数理研究所共同利用「確率測度の最適化と通信路容量」研究会
  • Place of Presentation: 統計数理研究所(東京都立川市)
  • Year and Date: 2010-07-27
• [Presentation] Minimum conditional entropy principle for irregular firing of cortical neurons (2010)
  • Author(s): Yasuhiro Tsubo
  • Organizer: Workshop : Fresh Perspectives of Computation in Neuronal Systems
  • Place of Presentation: 生理学研究所(愛知県岡崎市)
  • Year and Date: 2010-06-03
• [Remarks] (1)坪 泰宏,寺前 順之介.実施報告 「2012年度時限研究会「次世代情報処理における揺らぎと確率」研究会」 日本神経回路学会誌 19 (3) 153-155 (Sep. 2012)
• [Remarks] (2)坪 泰宏,招待講演「皮質神経細胞の不規則発火時系列が示唆する情報原理」脳科学若手の会第8回談話会「脳科学理論と実験の融合」(東京大学,東京)2012 年8 月4日
• [Remarks] (3)坪 泰宏,「神経細胞の多様な動的特性とその機能的役割」第1回ヘテロ・ニューロアナリシス研究会(仙台国際センター,仙台)2012 年7月24 日
• [Remarks] (4)坪 泰宏,「神経細胞における発火率分布の最適化」統計数理研究所共同利用「確率測度の最適化と通信路容量」研究会(統計数理研究所,立川・東京)2012 年 3 月12日
• [Remarks] (5)坪 泰宏,「神経細胞の動的膜特性の多様性」統計数理研究所「神経科学と統計科学の対話」研究会(統計数理研究所,立川・東京)2010年12月19日
• [Remarks]
  • URL: http://nct.brain.riken.jp/~tsubo/
• [Remarks]
  • URL: http://nct.brain.riken.jp/~tsubo/research.html