Regulation of hippocampal neural stem/progenitor cell proliferation and differentiation by adenosinevia equilibrative nucleoside transporter 1

• Project/Area Number: 22700325
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: Tohoku University
• Principal Investigator: MORIYA Takahiro 東北大学, 大学院・薬学研究科, 准教授 (80298207)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: アデノシン / アデノシントランスポーター / ENT1 / ニューロン新生 / 神経幹細胞 / トランスポーター / ENT

Research Abstract

We demonstrated that ENT1-mediated uptake of adenosine suppressed the proliferation of neural stem cells by inhibiting de novo synthesis of pyrimidine. Furthermore, we revealed that ENT1-mediated uptake of adenosine is involed in sleep-deprivation induced suppression of neurogenesis in the hippocampus.

Research Products

• [Journal Article] 中枢神経系作用薬の時間治療への応用の可能性 (2011)
  • Author(s): 守屋孝洋
  • Journal Title: ファルマシア Volume: 47巻 Pages: 618-622
  • NAID: 110009900986
• [Journal Article] Distinctive Effects of Arachidonic Acid and Docosahexaenoic Acid on Neural Stem/Progenitor Cells (2011)
  • Author(s): Sakayori M, Maekawa M, Numayama-Tsuruta K, Katura T, Moriya T, Osumi N
  • Journal Title: Genes to Cells Volume: 16巻 Pages: 778-790
  • Peer Reviewed
• [Journal Article] Period遺伝子の発現制御を介した概日時計のリセット機構に関する研究 (2010)
  • Author(s): 守屋孝洋
  • Journal Title: 日薬理誌 Volume: 135巻 Pages: 230-234
  • NAID: 10026544140
• [Journal Article] Effects of medial hypothalamic lesions on feeding-induced entrainment of locomotor activity and liver Per2 expression in Per2 : : luc mice (2010)
  • Author(s): Tahara Y, Hirao A, Moriya T, Kudo T, Shibata S
  • Journal Title: J Biol Rhythms Volume: 25巻 Pages: 9-18
  • Peer Reviewed
• [Journal Article] 15-Deoxy-Δ12, 14-Prostaglandin J2 Biphasically Regulates the Proliferation of Mouse Hippocampal Neural Progenitor Cells by Modulating the Redox State (2010)
  • Author(s): Katura T, Moriya T, Nakahata N
  • Journal Title: Mol Pharmacol Volume: 77巻 Pages: 601-611
  • Peer Reviewed
• [Journal Article] 15-Deoxy-Δ12,14-Prostaglandin J2 Biphasically Regulates the Proliferation of Mouse Hippocampal Neural Progenitor Cells by Modulating the Redox State (2010)
  • Author(s): Katura T, Moriya T, Nakahata N
  • Journal Title: Mol Pharmacol Volume: 77 Pages: 601-611
  • Peer Reviewed
• [Journal Article] Effects of medial hypothalainic lesions on feeding-induced entrainment of locomotor activity and liver Per2 expression in Per2::luc mice (2010)
  • Author(s): Tahara Y, Hirao A, Moriya T, Kudo T, Shibata S
  • Journal Title: J Biol Rhythms Volume: 25 Pages: 9-18
  • Peer Reviewed
• [Presentation] 神経幹細胞のリズムと抗うつ薬 (2011)
  • Author(s): 守屋孝洋、前川知子、中畑則道
  • Organizer: 第18回日本時間生物学会学術大会・シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2011-11-25
• [Presentation] 神経幹細胞のリズムと抗うつ薬 (2011)
  • Author(s): 守屋孝洋、前川知子、中畑則道
  • Organizer: 第18回日本時間生物学会学術大会・シンポジウム
  • Place of Presentation: 名古屋(招待講演)
  • Year and Date: 2011-11-25
• [Presentation] 神経幹細胞の概日リズムの制御機構と生理的役割 (2011)
  • Author(s): 守屋孝洋、前川知子、中畑則道
  • Organizer: 第64回日本自律神経学会総会・シンポジウム
  • Place of Presentation: 秋田
  • Year and Date: 2011-10-27
• [Presentation] 神経幹細胞の概日リズムの制御機構と生理的役割 (2011)
  • Author(s): 守屋孝洋、前川知子、中畑則道
  • Organizer: 第64回日本自律神経学会総会・シンポジウム
  • Place of Presentation: 秋田(招待講演)
  • Year and Date: 2011-10-27
• [Presentation] ERK1/2を介した胎生マウス線条体原基由来神経幹細胞の体内時計のリセット機構 (2010)
  • Author(s): 守屋孝洋
  • Organizer: 第17回日本時間生物学会学術大会
  • Place of Presentation: 早稲田大学国際会議場(東京)
  • Year and Date: 2010-11-21
• [Presentation] 拡散性ヌクレオシドトランスポーター1(ENT1)を介したアデノシン取込みによる海馬ニューロン新生調節機構 (2010)
  • Author(s): 守屋孝洋
  • Organizer: 第61回日本薬理学会北部会
  • Place of Presentation: 札幌コンベンションセンター(札幌市)
  • Year and Date: 2010-09-10
• [Presentation] 受動拡散型ヌクレオシドトランスポーター1を介したアデノシンによる神経幹細胞の増殖制御機構 (2010)
  • Author(s): 守屋孝洋
  • Organizer: 第33回日本神経科学大会(Neuro2010)
  • Place of Presentation: 神戸コンベンションセンター(神戸市)
  • Year and Date: 2010-09-03
• [Presentation] Extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated resetting of the circadian clock of the mouse embryonic brain-derived neural stem/progenitor cells (2010)
  • Author(s): Moriya T
  • Organizer: SRBR 12th Biennial Meeting
  • Place of Presentation: Sandestin Golf and Beach Resort (米国・フロリダ州・デスティン)
  • Year and Date: 2010-05-23
• [Presentation] Extracellular signal-regulated kinase 1/2 (ERK1/2)-mediated resetting of the circadian clock of the mouse embryonic brain-derived neural stem/progenitor cells (2010)
  • Author(s): Moriya T
  • Organizer: SRBR 12th Biennial Meeting
  • Place of Presentation: Sandestin Golf and Beach Resort(米国・フロリダ州・デスティン)
  • Year and Date: 2010-05-23