Molecular codes for neuronal individuality in neural circuit formation
| Project/Area Number |
22700326
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Gunma University |
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Principal Investigator |
KANEKO Ryosuke 群馬大学, 大学院・医学系研究科, 助教 (40390695)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 神経発生 / 多様性 / 神経回路 / バスケット細胞 / プロトカドヘリン / GABAニューロン / 小脳 / 遺伝子改変マウス / 進化 |
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| Research Abstract |
We have generated transgenic mice that genetically label individual cerebellar GABAergic neurons with red fluorescence. Moreover, several lines of clustered Pcdhs deficient mice have been generated and the Pcdh-a & b deficient mice showed motor abnormalities. These experiments support our hypothesis that protocadherins provide molecular codes for neuronal individuality in neural circuit formation.
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Report
(3 results)
Research Products
(15 results)
