| Project/Area Number |
22700331
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | University of Toyama |
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Principal Investigator |
OHKAWA Noriaki 富山大学, 大学院・医学薬学研究部(医学), 助教 (80416651)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 神経科学 / 神経新生 / スパイン / 長期増強(LTP) / 海馬 / ニューロン新生 / シナプス / 神経可塑性 / Zif268 |
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| Research Abstract |
In the adult hippocampus, newly born neurons are functionally integrated into existing circuits and play important roles in hippocampus-dependent memory. However, it remains unclear how neural plasticity regulates the integration pattern of new neurons into preexisting circuits. We had observed that LTP induction at 12-day after birth of new neurons increased later spinogenesis of their neurons. We then investigated the rate of circuit activity-dependent Zif268 expression, as indicator of the functional integration, in BrdU-labeled new born cells. When we induced LTP at 12-day after birth of new neurons, induction ratio of activity-dependent Zif268 expression in their neurons was significantly increased at 16-day after the LTP induction. This data strongly suggests that LTP induction at approximately 1-2-week after birth of new neurons enhances later functional integration of their neuron into activated circuits.
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