The role of D-serine in epilepsy
| Project/Area Number |
22700332
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | University of Toyama |
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Principal Investigator |
INOUE Ran 富山大学, 大学院・医学薬学研究部(医学), 助教 (70401817)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 分子 / 細胞神経科学 / D-セリン / セリンラセマーゼ / NMDA受容体 / てんかん / NDMA受容体 |
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| Research Abstract |
In this study, we examined the effect of D-serine deficiency on the seizures induced by a single injection of pentylenetetrazole(PTZ) using SR knockout(KO) mice. We found that, compared with wild-type(WT) mice, SR-KO mice showed the attenuation of seizure expression in terms of a significantly shortened duration of generalized seizures and resistance to generalized clonic-tonic seizures. Consistently, immunohistochemical analysis of c-Fos demonstrated that the level of c-Fos labeling induced by high-dose PTZ in the cerebral cortex, hippocampal CA1, hippocampal CA3, and the basolateral nucleus of the amygdala in WT mice was significantly higher than that in SR-KO mice. Moreover, PTZ induced an increase in extracellular glutamate level in the dentate gyrus of WT mice at two different time phases. However, such a PTZ-induced increase in glutamate level was completely inhibited in SR-KO mice. The present findings suggest that SR may be a target for the development of new therapeutic strategies for epileptic seizures.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Differential regional distribution of phosphorylated tau and synapseloss in the nucleus accumbens in tauopathy model mice.2011
Author(s)
Kambe T, Motoi Y, Inoue R, Kojima N, Tada N, Kimura T, Sahara N, Yamashita S, Mizoroki T, Takashima A, Shimada K, Ishiguro K, Mizuma H, Onoe H, Mizuno Y, Hattori N
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Journal Title
Neurobiology of Disease
Volume: 42
Pages: 404-414
Related Report
Peer Reviewed
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