Effects of activating the response of neuromodulators and their interactions by deep brain stimulation.

• Project/Area Number: 22700339
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: Osaka University
• Principal Investigator: NAITO Tomoyuki 大阪大学, 医学系・研究科, 助教 (90403188)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 深部脳刺激法 / ニューロモジュレータ / 逆相関法 / 非線形修飾効果 / 脳深部刺激 / 受容野構造 / 非線形性

Research Abstract

I have developed a method that describes the non-linear modulation effects from neuromodulator quantitatively with a combination of reverse-correlation method and non-linear response function estimation. Applying this method to the response of neurons in the lateral geniculate nucleus and primary visual cortex revealed that it was possible to visualize the non-linear response modulation by neuromodulators with this method.

Research Products

• [Journal Article] Surround suppression by high spatial frequency stimuli in the cat primary visual cortex (2011)
  • Author(s): Osaki H, Naito T, Sadakane O, Okamoto M, Sato H
  • Journal Title: Eur J Neurosci Volume: 33(5) Pages: 923-32
• [Journal Article] Surround suppression by high spatial frequency stimuli in the cat primary visual cortex (2011)
  • Author(s): Osaki H, Naito T, Sadaken O, Okamoto M, Sato H
  • Journal Title: European Journal of Neuroscience Volume: 33 Pages: 923-932
  • Peer Reviewed
• [Journal Article] Directional anisotropy of human motion perception depends on stimulus speed (2010)
  • Author(s): Naito T, Sato H, Osaka N
  • Journal Title: Vision Res Volume: 50(18) Pages: 1862-1866
• [Journal Article] Directional anisotropy of human motion perception depends on stimulus speed (2010)
  • Author(s): T.Naito, H.Sato, N.Osaka
  • Journal Title: Vision Research Volume: 50 Pages: 1862-1866
  • Peer Reviewed
• [Presentation] Spatial-frequency and stimulus size dependent response modulation sharpens orientation tuning generated by elliptical receptive field in the cat lateral geniculate nucleus (2011)
  • Author(s): Naofumi Suematsu, Tomoyuki Naito, Hiromichi Sato
  • Organizer: Society for Neuro science 2011
  • Place of Presentation: Washington D.C.USA
  • Year and Date: 2011-11-13
• [Presentation] The effect of stimulus size and luminance contrast on the spatial frequency tuning of the human visual perception (2011)
  • Author(s): 内藤智之、末松尚史、佐藤宏道
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-14
• [Presentation] Properties and mechanisms of orientation tuning of the cat lateral geniculate nucleus (2011)
  • Author(s): H.Sato, T.Naito, H.Osaki, N.Suematsu, O.Sadakane, M.Okamoto, S.Shimegi
  • Organizer: 第8回IBRO
  • Place of Presentation: Florence, Italy
  • Year and Date: 2011-07-17
• [Presentation] Spatial-frequency and stimulus size dependent response modulation sharpens orientation tuning generated by elliptical receptive field in the cat lateral geniculate nucleus (2011)
  • Author(s): Suematsu N, Naito T, Sato H
  • Organizer: Society for Neuroscience
  • Place of Presentation: Washington D. C. USA
• [Presentation] Elliptical linear receptive field and non-linear response modulation generating orientation selectivity in the lateral geniculate nucleus of the cat (2011)
  • Author(s): 内藤智之、末松尚史、佐藤宏道
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
• [Presentation] ネコ外側膝状体ニューロンの受容野及び方位選択性の詳細検討 (2011)
  • Author(s): 末松尚史、内藤智之、佐藤宏道
  • Organizer: 第15回視覚科学フォーラム
  • Place of Presentation: 大阪
• [Presentation] Detection process for biased target position based on the Bayesian estimation procedure (2011)
  • Author(s): Naito T, Matsumoto E, Kabata T
  • Organizer: ECVP2011
  • Place of Presentation: Toulouse, France
• [Presentation] ネコ外側膝状体ニューロンの受容野時空間構造と方位選択性 (2010)
  • Author(s): 末松尚史、内藤智之、佐藤宏道
  • Organizer: 第103回近畿生理学談話会
  • Place of Presentation: 大阪
• [Presentation] Properties and mechanisms of orientation tuning of the cat lateral geniculate nucleus
  • Author(s): Sato H, Naito T, Osaki H, Suematsu N, Sadakane O, Okamoto M, Shimegi S
  • Organizer: 第8回IBRO Florence
  • Place of Presentation: Italy
• [Book] 初期知覚の基礎「心理学入門:脳科学と視覚情報処理」 (2011)
  • Author(s): 内藤智之
  • Publisher: 培風館(印刷中)
• [Book] 初期知覚の基礎「心理学入門:脳科学と視覚情報処理」 (2011)
  • Author(s): 内藤智之, 他
  • Total Pages: 229
  • Publisher: 培風館
• [Book] 映画で馬車の車輪が進行方向と逆向きに回転するように見えることがあるのはなぜか?「視覚のサイエンス」 (2010)
  • Author(s): 内藤智之、佐藤宏道
  • Publisher: 文光堂
• [Book] 脳磁図(MEG)を用いた研究:仮現運動刺激に対するヒトの方向選択性「脳イメージング入門:心理学からのアプローチ」 (2010)
  • Author(s): 内藤智之
  • Publisher: 培風館
• [Book] 映画で馬車の車輪が進行方向と逆向きに回転するように見えることがあるのはなぜか?「視覚のサイエンス」 (2010)
  • Author(s): 内藤智之、佐藤宏道, 他
  • Total Pages: 249
  • Publisher: 文光堂
• [Book] 脳磁図(MEG)を用いた研究:仮現運動刺激に対するヒトの方向選択性「脳イメージング入門:心理学からのアプローチ」 (2010)
  • Author(s): 内藤智之, 他
  • Total Pages: 199
  • Publisher: 培風館
• [Remarks] ホームページ等所属研究室ホームページ
  • URL: http://www.vision.hss.osaka-u.ac.jp/index.html
• [Remarks] 個人ホームページ
  • URL: https://sites.google.com/site/naitotomoyuki/
• [Remarks]
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