Molecular basis of CO_2 sensing in the mouse olfactory system

• Project/Area Number: 22700341
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: Nara Medical University
• Principal Investigator: TAKAHASHI Hiroo 奈良県立医科大学, 医学部, 助教 (20390685)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 嗅細胞 / CO_2 / CO2

Research Abstract

Mice can detect CO_2 at concentrations around the average atmospheric level by olfaction. Previous study reported that there is a unique subset of olfactory sensory neurons(OSNs), which act as a sensor for CO_2 in the mouse olfactory epithelium(OE). In this study, we found that at least two novel subsets of OSNs respond to CO_2.These results suggest that mice sense CO_2 with some subsets of OSNs in the OE.

Research Products

• [Journal Article] 5T4 Glycoprotein regulates the sensory input-dependent development of a specific subtype of newborn interneurons in the mouse olfactory bulb (2012)
  • Author(s): Yoshihara S, Takahashi H, Nishimura N, Naritsuka H, Shirao T, Hirai H, Yoshihara Y, Mori K, Stern P. L. and Tsuboi A
  • Journal Title: The Journal of Neuroscience Volume: Vol.32 Issue: 6 Pages: 2217-2226
  • DOI: 10.1523/jneurosci.5907-11.2012
  • Peer Reviewed
• [Journal Article] 脳における匂い感覚地図の形成メカニズムFood and Food Ingredients Journal of Japan (2011)
  • Author(s): 高橋弘雄、坪井昭夫
  • Journal Title: 和文総説 Volume: Vol.216 Pages: 100-106
• [Journal Article] Neuropilin-2 is required for the proper targeting of ventral glomeruli in the mouse olfactory bulb (2010)
  • Author(s): Takahashi H, Yoshihara S, Nishizumi H, and Tsuboi A
  • Journal Title: Molecular and Cellular Neuroscience Volume: Vol.44 Issue: 3 Pages: 233-245
  • DOI: 10.1016/j.mcn.2010.03.010
  • Peer Reviewed
• [Journal Article] 脳における匂い感覚地図の形成メカニズAroma Research (2010)
  • Author(s): 高橋弘雄、吉原誠一、坪井昭夫
  • Journal Title: 和文総説 Volume: Vol.11 Pages: 224-229
• [Journal Article] Neuropilin-2 is required for the proper targeting of ventral glomeruli in the mouse olfactory bulb. (2010)
  • Author(s): H.Takahashi, et al.
  • Journal Title: Molecular and Cellular Neuroscience Volume: 44 Pages: 233-245
  • Peer Reviewed
• [Presentation] Molecular basis of CO_2 sensing in the mouse olfactory system (2012)
  • Author(s): 高橋弘雄, 他
  • Organizer: The International Symposium on Olfaction and Taste
  • Place of Presentation: スウェーデンStockholm Waterfront
  • Year and Date: 2012-06-24
• [Presentation] Molecular basis of CO_2 sensing in the mouse olfactory system (2010)
  • Author(s): 高橋弘雄, 他
  • Organizer: 第33回日本神経科学会大会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-09-03
• [Presentation] Molecular basis of CO_2 sensing in the mouse olfactory system. (2010)
  • Author(s): 高橋弘雄, 他
  • Organizer: 第33回日本神経科学会大会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-09-03
• [Remarks]
• [Remarks] 研究室HP
  • URL: http://www.naramed-u.ac.jp/~amrc-lab1/