| Project/Area Number |
22700342
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Neuroscience in general
|
|---|
| Research Institution | Keio University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | 発生 / 発達 / 再生神経科学 / 神経科学 / アストロサイト / 脊髄損傷 / 細胞移動 |
|---|
| Research Abstract |
Based on the observation that inhibition of Glycogen Synthase Kinase-3(GSK-3) stimulates the migration of astrocytes, the applicant was able to pharmacologically stimulate this beneficial effect of reactive astrocytes : the administration of a specific inhibitor of GSK-3 after contusive SCI resulted in an accelerated migration of reactive astrocytes that secluded inflammatory cells, reduced the size of the lesions scar, spared more myelinated fibers, and significantly enhanced functional improvement. These findings suggest that the pharmacological stimulation of reactive astrocyte migration holds promise as a new therapeutic strategy for the treatment of spinal cord injury.
|
