The study of molecular basis underlying the motor control in the basal ganglia.

• Project/Area Number: 22700344
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: 財団法人東京都医学総合研究所 (2011); Tamagawa University (2010)
• Principal Investigator: ARIMURA Nariko 財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 主席研究員 (20420375)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 行動神経科学 / 脳・神経 / 大脳基底核 / 行動制御 / 大脳 / 基底核 / 分子基盤

Research Abstract

It is essential to understand the property of neural population consisting of the brain and the constitution of neural network in familiarization with the variety of brain function and the nerve disease. However, in the higher brain function including the mood and motor control, it still lacks the global analysis to reveal what kinds of neuronal populations showing the unique gene expression patterns interplay with several neuronal populations using what molecular mechanisms, and which neural function was generated. In this study, I analyzed the gene expression pattern in the globus pallidus, as an output device of the basal ganglia mediated mood and motor control.

Research Products

• [Journal Article] Local application of Neurotrophins specifies axon through inositol 1, 4, 5-trisphosphate/Ca2+/calmodulin-dependent protein kinases (2011)
  • Author(s): Nakamuta, S., Funahashi, Y., Namba, T., Arimura, N., Picciotto, MR., Tokumitsu, H., Soderling, TR., Sakakibara, A., Miyata, T., Kamiguchi, H., and Kaibuchi, K
  • Journal Title: Science Signalling Volume: 4 Pages: 76-76
  • Peer Reviewed
• [Journal Article] 認知と運動の統合過程を支える神経基盤 (2011)
  • Author(s): 星英司、中山義久、山形朋子、佐賀洋介、橋本雅史、有村奈利子、丹治順
  • Journal Title: Brain and Nerve Volume: 63 Pages: 59-68
  • Peer Reviewed
• [Journal Article] 補足運動野と前補足運動野 (2011)
  • Author(s): 丹治順、中山義久、山形朋子、佐賀洋介、橋本雅史、有村奈利子、星英司
  • Journal Title: Clinical Neuroscience Volume: 28 Pages: 1121-24
  • Peer Reviewed
• [Journal Article] Local application of Neurotrophins specifies axon through inositol 1,4,5-trisphosphate/Ca2+/calmodulin-dependent protein kinases (2011)
  • Author(s): Shinichi Nakamuta
  • Journal Title: Science Signaling Volume: 15(in press)
  • Peer Reviewed
• [Journal Article] 補足運動野と前補足運動野 (2011)
  • Author(s): 丹治順
  • Journal Title: Clinical Neuroscience Volume: 28 Pages: 1121-1124
• [Presentation] A comparison of neuronal activity of globus pallidus and premotor cortex in retrieving a virtual action plan instructed by a visual object and in developing a physical motor plan (2011)
  • Author(s): 有村奈利子
  • Organizer: Neuroscience2011
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-17
• [Presentation] Role of the globus pallidus in action planning as mediated by the abstract representation of action. (2011)
  • Author(s): 有村奈利子
  • Organizer: 第一回東北大学脳科学国際シンポジウム
  • Place of Presentation: 東北大学生命科学プロジェクト研究棟(宮城県)
  • Year and Date: 2011-01-21
• [Presentation] A comparison of neuronal activity of globus pallidus and premotor cortex in retrieving a virtual action plan instructed by a visual object and in developing a physical motor plan (2011)
  • Author(s): Arimura N, Nakayama Y, Yamagata T, Tanji J, & Hoshi E
  • Organizer: Neuro2011
  • Place of Presentation: 横浜
• [Presentation] Role of the globus pallidus in action planning as mediated by the abstract representation of action (2011)
  • Author(s): Arimura N, Nakayama Y, Yamagata T, Saga Y, Tanji J, Hoshi E
  • Organizer: 第一回東北大学脳科学国際シンポジウム
  • Place of Presentation: 宮城
• [Presentation] Role of the globus pallidus in action planning as mediated by the abstract representation of action. (2010)
  • Author(s): 有村奈利子
  • Organizer: 41th NIPS International Symposium
  • Place of Presentation: 生理学研究所(愛知県)
  • Year and Date: 2010-12-16
• [Presentation] Role of the globus pallidus in action planning as mediated by the abstract representation of action. (2010)
  • Author(s): 有村奈利子
  • Organizer: Neuroscience2010
  • Place of Presentation: SanDiego Convention Center (USA)
  • Year and Date: 2010-11-17
• [Presentation] 運動の表象表現を介した運動計画における大脳基底核と前頭前野の関与 (2010)
  • Author(s): 有村奈利子
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸コンベンションセンター(兵庫県)
  • Year and Date: 2010-09-03
• [Presentation] Role of the globus pallidus in action planning as mediated by the abstract representation of action (2010)
  • Author(s): Arimura N, Nakayama Y, Yamagata T, Saga Y, Tanji J, Hoshi E
  • Organizer: 41th NIPS International Symposium
  • Place of Presentation: 岡崎
• [Presentation] Role of the globus pallidus in action planning as mediated by the abstract representation of action (2010)
  • Author(s): Arimura N, Nakayama Y, Yamagata T, Saga Y, Tanji J, Hoshi E
  • Organizer: Neuroscience2010
  • Place of Presentation: San Diego
• [Presentation] 運動の表象表現を介した運動計画における大脳基底核と前頭前野の関与 (2010)
  • Author(s): 有村奈利子、中山義久、山形朋子、佐賀洋介、丹治順、星英司
  • Organizer: Neuro2010
  • Place of Presentation: 神戸
• [Remarks]
  • URL: http://www.igakuken.or.jp/frontal-lobe/
• [Remarks]
  • URL: http://www.igakuken.or.jp/frontal-lobe/
• [Remarks]
  • URL: http://www.tamagawa.ac.jp/teachers/hoshi/index.htm