| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
By using a bioinformatical method, we identified UBL3 as a highly conserved posttranslational modifier. We found that UBL3 were localized at the plasma membrane and attached to other proteins like an ubiquitin protein. However, the functional role of UBL3 is still unknown. To elucidate roles of UBL3, we searched for interaction protein with UBL3.As a result, we identified several UBL3-binding proteins. One UBL3-binding protein enhanced UBL3ylation which is a posttranslational modification via UBL3.These findings suggest that UBL3 may play a pivotal role as an essential component of a novel membrane localization system.
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