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Endocytic pathways controlling neuronal growth cone guidance

Research Project

Project/Area Number 22700353
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neuroscience in general
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

TOJIMA Takuro  独立行政法人理化学研究所, 神経成長機構研究チーム, 研究員 (00373332)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords神経成長円錐 / 軸索ガイダンス / クラスリン依存性エンドサイトーシス / カルシニューリン / CaMキナーゼII / Cdk5 / エンドサイトーシス / クラスリン / カルシウム / Dephosphin
Research Abstract

The neuronal growth cone navigates the axon along the correct path by sensing extracellular guidance cues. We previously demonstrated that, downstream of Ca2+signals, growth cone attraction and repulsion are driven by asymmetric exocytosis and endocytosis, respectively. In this project, we identified the signaling pathways that link Ca2+signals with endocytosis for bidirectional growth cone guidance.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (18 results)

All 2011 2010 Other

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (8 results) Book (2 results) Remarks (3 results)

  • [Journal Article] 神経軸索突起をターゲットへ導く細胞内メカニズム2011

    • Author(s)
      戸島拓郎,秋山博紀,上口裕之
    • Journal Title

      生物物理

      Volume: 51 Pages: 214-217

    • NAID

      10029482440

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Second messengers and membrane trafficking direct and organize growth cone steering2011

    • Author(s)
      Takuro Tojima, Jacob H. Hines, John R. Henley, Hiroyuki Kamiguchi
    • Journal Title

      Nature Reviews Neuroscience

      Volume: 12 Pages: 191-203

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Second messengers and membrane trafficking direct and organize growthcone steering2011

    • Author(s)
      Takuro Tojima
    • Journal Title

      Nature Reviews Neuroscience

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] エンドサイトーシスによる神経軸索ガイダンス制御2010

    • Author(s)
      戸島拓郎
    • Journal Title

      神経科学ニュース

      Volume: 184 Pages: 20-21

    • Related Report
      2011 Final Research Report
  • [Journal Article] Asymmetric clathrin-mediated endocytosis drives repulsive growth coneguidance2010

    • Author(s)
      Takuro Tojima
    • Journal Title

      Neuron

      Volume: 66 Pages: 370-377

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 神経軸索ガイダンスの方向極性を決定するカルシウム依存性エンドサイトーシス制御機構2011

    • Author(s)
      戸島拓郎,糸総るり香,上口裕之
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-14
    • Related Report
      2011 Final Research Report
  • [Presentation] 神経軸索ガイダンスの方向極性を決定するカルシウム依存性エンドサイトーシス制御2011

    • Author(s)
      戸島拓郎
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] The signaling pathways controlling clathrin-mediated endocytosis for bidirectional growth cone guidance2011

    • Author(s)
      Takuro Tojima, Rurika Itofusa, Hiroyuki Kamiguchi
    • Organizer
      8th IBRO World Congress of Neuroscience
    • Place of Presentation
      Florence
    • Year and Date
      2011-07-14
    • Related Report
      2011 Final Research Report
  • [Presentation] Attractive axon guidance requires phosphatidylinositol 3-kinase-dependent membrane trafficking in the growth cone2011

    • Author(s)
      Hiroki Akiyama, Takuro Tojima, Hiroyuki Kamiguchi
    • Organizer
      8th IBRO World Congress of Neuroscience
    • Place of Presentation
      Florence
    • Year and Date
      2011-07-14
    • Related Report
      2011 Final Research Report
  • [Presentation] 神経軸索ガイダンスを制御するエンドサイトーシス調節経路:CaMキナーゼIIとカルシニューリンの拮抗作用2011

    • Author(s)
      戸島拓郎,糸総るり香,上口裕之
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      札幌
    • Year and Date
      2011-06-27
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 膜トラフィッキングによる神経軸索ガイダンス駆動機構2010

    • Author(s)
      戸島拓郎
    • Organizer
      第5回メカノセンシング研究会
    • Place of Presentation
      京都
    • Year and Date
      2010-11-25
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 非対称性クラスリン依存性エンドサイトーシスによる成長円錐ガイダンスの駆動機構2010

    • Author(s)
      戸島拓郎,糸総るり香,上口裕之
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-02
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 神経成長円錐ガイダンスにおけるクラスリン依存性エンドサイトーシスの役割2010

    • Author(s)
      戸島拓郎
    • Organizer
      第62回日本細胞生物学会大会
    • Place of Presentation
      大阪
    • Year and Date
      2010-05-19
    • Related Report
      2010 Annual Research Report
  • [Book] The driving machinery for growth cone navigation. Cytoskeleton of the Nervous System, Advances in Neurobiology2011

    • Author(s)
      Takuro Tojima, Hiroyuki Kamiguchi
    • Publisher
      Springer, New York
    • Related Report
      2011 Final Research Report
  • [Book] The driving machinery for growth cone navigation. In "Cytoskeleton of the Nervous System, Advances in Neurobiology" vol 3(R.A.Nixon, A.Yuan Eds.)2011

    • Author(s)
      Takuro Tojima
    • Publisher
      Springer, New York
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://tojimat.web.fc2.com/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.brain.riken.jp/jp/h_kamiguchi.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.brain.riken.jp/jp/h_kamiguchi.html

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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