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Analysis on Inhibitory circuit control of critical period-Comparative study in mice and birds.

Research Project

Project/Area Number 22700358
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neuroscience in general
Research Institution沖縄科学技術大学院大学 (2011)
The Institute of Physical and Chemical Research (2010)

Principal Investigator

SUGIYAMA Yoko (YAZAKI Yoko)  沖縄科学技術大学院大学, 臨界期の研究メカニズム研究ユニット, 准教授 (00317512)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords行動神経学 / 臨界期 / 歌学習 / GABA / 聴覚 / 可塑性 / 抑制性機構 / 感覚-運動学習
Research Abstract

The timing of critical period of ocular dominance plasticity in mice are regulated with cortical inhibitory circuit development. In this study we have tested whether this principle can be applied to the critical period in bird song learning. Early GABA enhancement in the developmental birds brain disrupted later song learning in male zebra finches by closing sensory learning period earlier. Here we suggested conserved critical period mechanism, inhibitory circuit control of critical period.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (7 results)

All 2011 2010

All Journal Article (1 results) Presentation (6 results)

  • [Journal Article] 感覚情報をもとに神経回路を形成する時期の決定-臨界期を制御する神経メカニズムの解明2011

    • Author(s)
      杉山陽子(矢崎陽子)、ヘンシュ貴雄
    • Journal Title

      実験医学

      Volume: 29(4) Pages: 533-537

    • Related Report
      2011 Final Research Report
  • [Presentation] GABA enhancement prevents an extended sensory learning period by song isolation in juvenile zebra finch2011

    • Author(s)
      杉山(矢崎)陽子
    • Organizer
      The 41th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-11-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Inhibitory circuit control of developmental 'critical period'2011

    • Author(s)
      杉山(矢崎)陽子
    • Organizer
      第82回日本動物学会シンポジウム
    • Place of Presentation
      旭川市クリスタルホール(招待講演)
    • Year and Date
      2011-09-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Inhibitory circuit control of developmental 'critical period'2011

    • Author(s)
      杉山陽子(矢崎陽子)
    • Organizer
      第82回日本動物学会シンポジウム
    • Place of Presentation
      旭川
    • Related Report
      2011 Final Research Report
  • [Presentation] GABA enhancement prevents an extended sensory learning period by song isolation in juvenile zebra finch2011

    • Author(s)
      Yoko Yazaki-Sugiyama, Jason Kushner, Neal A Hessler, Takao K Hensch
    • Organizer
      The 41th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Washington DC USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Bidirectional plasticity in fast-spiking GABAcircuits by visual experience2010

    • Author(s)
      杉山陽子(矢崎陽子)
    • Organizer
      The Fifth International Neural Microcircuitry Conference
    • Place of Presentation
      Tokyo
    • Related Report
      2011 Final Research Report
  • [Presentation] Bidirectional plasticity in fast-spiking GABA circuits by visual experience.2010

    • Author(s)
      杉山(矢崎)陽子
    • Organizer
      The Fifth International Neural Microcircuitry Conference
    • Place of Presentation
      東京、未来館
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-10-28  

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