Molecular Mechanisms underlying acquisition of neuronal identity in olfactory sensory neurons

• Project/Area Number: 22700364
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: The University of Tokyo
• Principal Investigator: TAKEUCHI Haruki 東京大学, 大学院・理学系研究科, 特任助教 (70548859)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 神経回路網 / 神経回路形成 / 嗅覚 / 軸索投射 / 神経科学 / 神経活動 / 分子生物学 / 発生 / 嗅覚受容体 / 神経回路

Research Abstract

The assembly of the functional neural circuit is one of the most complex developmental processes. Unraveling the mechanisms involved is vital for advancing basic scientific understanding. In the mouse olfactory system, expressed olfactory receptor(OR) plays a pivotal role in the axonal projection of olfactory sensory neurons(OSNs). However, it remains unknown about the nature of the signals for activating OR proteins. In this study, we focused on ligand-independent basal activity and found that each OR has a unique level of basal activity and signaling levels of the OR-derived basal activity regulate the projection site of OSN axons.

Research Products

• [Journal Article] Sequential Arrival and Graded Secretion of Sema3F by Olfactory Neuron Axons Specify Map Topography at the Bulb (2010)
  • Author(s): Haruki Takeuchi, Kasumi Inokuchi, Mari Aoki, Fumikazu Suto, Akio Tsuboi, Ikuo Matsuda, Misao Suzuki, Atsu Aiba, Shou Serizawa, Yoshihiro Yoshihara, Hajime Fujisawa and Hitoshi Sakano
  • Journal Title: Cell Volume: 141 Pages: 1056-1067
  • Peer Reviewed
• [Journal Article] 嗅覚神経地図形成の時空的制御 (2010)
  • Author(s): 竹内春樹、井ノ口霞、青木真理、坂野仁
  • Journal Title: 実験医学 Volume: 28巻 Pages: 1756-1760
• [Journal Article] 嗅覚神経地図形成の時空的制御 (2010)
  • Author(s): 竹内春樹
  • Journal Title: 実験医学 Volume: 28 Pages: 1756-1760
• [Presentation] 嗅覚系における背腹軸方向の軸索投射の分子基盤 (2011)
  • Author(s): 竹内春樹
  • Organizer: 日本分子生物学会
  • Place of Presentation: 横浜
• [Presentation] Molecular mechanisms of dorso-ventral topographic map formation in the mouse olfactory system (2011)
  • Author(s): Haruki Takeuchi
  • Organizer: 日本分子生物学会
  • Place of Presentation: 横浜
• [Presentation] Sequential Arrival and Graded Secretion of Sema3F by Olfactory Neuron Axons Specify Map Topography at the Bulb (2010)
  • Author(s): Haruki Takeuchi
  • Organizer: Keystone Symposia Synapses : Formation, Function and Misfunction April 11-15
  • Place of Presentation: Utah, USA
• [Presentation] Sequential Arrival and Graded Secretion of Sema3F by Olfactory Neuron Axons Specify Map Topography at the Bulb (2010)
  • Author(s): Haruki Takeuchi
  • Organizer: Keystone Symposia Synapses : Formation, Function and Misfunction
  • Place of Presentation: Utah, USA