Leukotrienes in nociceptive pathway and neuropathic pain.

• Project/Area Number: 22700371
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Hyogo Medical University
• Principal Investigator: KOBAYASHI Kimiko 兵庫医科大学, 医学部, 助教 (70418961)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 神経障害性疼痛 / ロイコトリエン / ロイコトリエン受容体 / 脊髄後角 / 後根神経節 / マイクログリア / 末梢神経損傷 / ロイコトリエン合成酵素 / ロイコリエン

Research Abstract

Leukotriene(LT) s belong to a large family of lipid mediators. LTs are known to be important factors in a variety of local and systemic diseases and allergic/inflammatory diseases. We examined whether LTs were implicated in neuropathic pain following peripheral nerve injury. Using the SNI model in rats, we investigated the expression of LT synthases and receptors mRNAs in the spinal cord and the roles on the pain behaviors. LTs and the receptors may be involved in the development of mechanical allodynia after peripheral nerve injury.

Research Products

• [Journal Article] Up-regulation of platelet-activating factor synthases and its receptor in spinal cord contribute to development of neuropathic pain following peripheral nerve injury. (2012)
  • Author(s): Okubo M, Yamanaka H, Kobayashi K, Kanda H, Dai Y, Noguchi K.
  • Journal Title: Mol Pain Volume: 8 Pages: 8-8
  • DOI: 10.1186/1744-8069-8-8
  • Peer Reviewed
• [Journal Article] Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain. (2010)
  • Author(s): Okubo M, Yamanaka H, Kobayashi K, Noguchi K.
  • Journal Title: Glia Volume: 58 Issue: 5 Pages: 599-610
  • DOI: 10.1002/glia.20948
  • Peer Reviewed
• [Journal Article] Expression of leukotriene receptors in the rat dorsal root ganglion and the effects on pain behaviors (2010)
  • Author(s): Okubo M, Yamanaka H, Kobayashi K, Fukuoka T, Dai Y, Noguchi K.
  • Journal Title: Mol Pain Volume: 17(57)
  • DOI: 10.1186/1744-8069-6-57
  • Peer Reviewed
• [Journal Article] Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain. (2010)
  • Author(s): Okubo M, Yamanaka H, Kobayashi K, Noguchi K
  • Journal Title: Glia Volume: 58 Pages: 599-610
  • Peer Reviewed
• [Journal Article] Expression of leukotriene receptors in the rat dorsal root ganglion and the effects on pain behaviors (2010)
  • Author(s): Okubo M, Yamanaka H, Kobayashi K, Fukuoka T, Dai Y, Noguchi K
  • Journal Title: Mol Pain Volume: 17 Pages: 57-57
  • Peer Reviewed
• [Presentation] Expression of leukotriene receptors in the rat dorsal root ganglion and the effect on pain behaviors (2011)
  • Author(s): Okubo M, Yamanaka H, Kobayashi K, Fukuoka T, Dai Y Noguchi K
  • Organizer: The 41th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington DC
  • Year and Date: 2011-11-15
• [Presentation] ラット後根神経節におけるロイコトリエン受容体の発現と疼痛行動への関与 (2011)
  • Author(s): 大久保正道, 山中博樹, 小林希実子, 野口光一
  • Organizer: 第33回日本疼痛学会
  • Place of Presentation: 愛媛
  • Year and Date: 2011-07-22
• [Presentation] Platelet-activating factor biosynthesis in spinal cord contributes to neuropathic pain following peripheral nerve injury (2010)
  • Author(s): Okubo M, Yamanaka H, Kobayashi K, Noguchi K.
  • Organizer: 13th World Congress on Pain(IASP)
  • Place of Presentation: Montreal
  • Year and Date: 2010-08-30
• [Presentation] 末梢神経損傷後に脊髄で増加する血小板活性化因子(PAF)は神経障害性疼痛に関与する (2010)
  • Author(s): 大久保正道, 山中博樹, 小林希実子, 野口光一
  • Organizer: 第32回日本疼痛学会
  • Place of Presentation: 京都
  • Year and Date: 2010-07-02