Leukotrienes in nociceptive pathway and neuropathic pain.
| Project/Area Number |
22700371
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 神経障害性疼痛 / ロイコトリエン / ロイコトリエン受容体 / 脊髄後角 / 後根神経節 / マイクログリア / 末梢神経損傷 / ロイコトリエン合成酵素 / ロイコリエン |
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| Research Abstract |
Leukotriene(LT) s belong to a large family of lipid mediators. LTs are known to be important factors in a variety of local and systemic diseases and allergic/inflammatory diseases. We examined whether LTs were implicated in neuropathic pain following peripheral nerve injury. Using the SNI model in rats, we investigated the expression of LT synthases and receptors mRNAs in the spinal cord and the roles on the pain behaviors. LTs and the receptors may be involved in the development of mechanical allodynia after peripheral nerve injury.
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Report
(3 results)
Research Products
(9 results)
