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Leukotrienes in nociceptive pathway and neuropathic pain.

Research Project

Project/Area Number 22700371
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Nerve anatomy/Neuropathology
Research InstitutionHyogo Medical University

Principal Investigator

KOBAYASHI Kimiko  兵庫医科大学, 医学部, 助教 (70418961)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords神経障害性疼痛 / ロイコトリエン / ロイコトリエン受容体 / 脊髄後角 / 後根神経節 / マイクログリア / 末梢神経損傷 / ロイコトリエン合成酵素 / ロイコリエン
Research Abstract

Leukotriene(LT) s belong to a large family of lipid mediators. LTs are known to be important factors in a variety of local and systemic diseases and allergic/inflammatory diseases. We examined whether LTs were implicated in neuropathic pain following peripheral nerve injury. Using the SNI model in rats, we investigated the expression of LT synthases and receptors mRNAs in the spinal cord and the roles on the pain behaviors. LTs and the receptors may be involved in the development of mechanical allodynia after peripheral nerve injury.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (9 results)

All 2012 2011 2010

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (4 results)

  • [Journal Article] Up-regulation of platelet-activating factor synthases and its receptor in spinal cord contribute to development of neuropathic pain following peripheral nerve injury.2012

    • Author(s)
      Okubo M, Yamanaka H, Kobayashi K, Kanda H, Dai Y, Noguchi K.
    • Journal Title

      Mol Pain

      Volume: 8 Pages: 8-8

    • DOI

      10.1186/1744-8069-8-8

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain.2010

    • Author(s)
      Okubo M, Yamanaka H, Kobayashi K, Noguchi K.
    • Journal Title

      Glia

      Volume: 58 Issue: 5 Pages: 599-610

    • DOI

      10.1002/glia.20948

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of leukotriene receptors in the rat dorsal root ganglion and the effects on pain behaviors2010

    • Author(s)
      Okubo M, Yamanaka H, Kobayashi K, Fukuoka T, Dai Y, Noguchi K.
    • Journal Title

      Mol Pain

      Volume: 17(57)

    • DOI

      10.1186/1744-8069-6-57

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain.2010

    • Author(s)
      Okubo M, Yamanaka H, Kobayashi K, Noguchi K
    • Journal Title

      Glia

      Volume: 58 Pages: 599-610

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of leukotriene receptors in the rat dorsal root ganglion and the effects on pain behaviors2010

    • Author(s)
      Okubo M, Yamanaka H, Kobayashi K, Fukuoka T, Dai Y, Noguchi K
    • Journal Title

      Mol Pain

      Volume: 17 Pages: 57-57

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Expression of leukotriene receptors in the rat dorsal root ganglion and the effect on pain behaviors2011

    • Author(s)
      Okubo M, Yamanaka H, Kobayashi K, Fukuoka T, Dai Y Noguchi K
    • Organizer
      The 41th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      Washington DC
    • Year and Date
      2011-11-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] ラット後根神経節におけるロイコトリエン受容体の発現と疼痛行動への関与2011

    • Author(s)
      大久保正道, 山中博樹, 小林希実子, 野口光一
    • Organizer
      第33回日本疼痛学会
    • Place of Presentation
      愛媛
    • Year and Date
      2011-07-22
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Platelet-activating factor biosynthesis in spinal cord contributes to neuropathic pain following peripheral nerve injury2010

    • Author(s)
      Okubo M, Yamanaka H, Kobayashi K, Noguchi K.
    • Organizer
      13th World Congress on Pain(IASP)
    • Place of Presentation
      Montreal
    • Year and Date
      2010-08-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 末梢神経損傷後に脊髄で増加する血小板活性化因子(PAF)は神経障害性疼痛に関与する2010

    • Author(s)
      大久保正道, 山中博樹, 小林希実子, 野口光一
    • Organizer
      第32回日本疼痛学会
    • Place of Presentation
      京都
    • Year and Date
      2010-07-02
    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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