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Clarification of epileptogenicity using human brain slices in vitro

Research Project

Project/Area Number 22700376
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Nerve anatomy/Neuropathology
Research InstitutionNiigata University

Principal Investigator

KITAURA Hiroki  新潟大学, 脳研究所, 助教 (80401769)

Research Collaborator KAKITA Akiyoshi  新潟大学, 脳研究所, 教授 (80281012)
FUKUDA Masafumi  新潟大学, 医歯学総合病院, 講師 (00361907)
KAMEYAMA Shigeki  国立病院機構, 西新潟中央病院, 院長
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywordsてんかん / イメージング / 電気生理 / フラビン蛍光 / 大脳皮質 / 急性スライス標本 / 光学的イメージング
Research Abstract

Epilepsy is one of the major neurological disorders in Japan. It is believed that hyper-excitability of the pyramidal neurons in the cerebral cortex contributes to epileptogenicity. However, the precise mechanism of the alteration was not still clarified. We struggled to observe spatiotemporal dynamics of epileptic activities using human brain slices taken from epileptic patients. As a result, we found unique epileptiform propagation of the activities in epileptogenic tissues but not in control tissues.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (18 results)

All 2012 2011 2010

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (9 results)

  • [Journal Article] Periventricular nodular heterotopia functionally couples with the overlying hippocampus.2012

    • Author(s)
      Kitaura H
    • Journal Title

      Epilepsia

      Volume: 53 Issue: 7 Pages: 127-131

    • DOI

      10.1111/j.1528-1167.2012.03509.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epidermoid cyst involving the medial temporal lobe : surgical pathologic features of the epileptogenic lesion.2012

    • Author(s)
      Hiraishi T, Oishi M, Kitaura H, Ryufuku M, Fu YJ, Fukuda M, Takahashi H, Fujii Y, Kakita A
    • Journal Title

      Neturopathology

      Volume: 32(2) Pages: 196-201

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epidermoid cyst involving the medial temporal lobe : surgical pathologic features of the epileptogenic lesion2012

    • Author(s)
      Hiraishi T, et al.
    • Journal Title

      Neuropathology

      Volume: 32 Issue: 2 Pages: 196-201

    • DOI

      10.1111/j.1440-1789.2011.01243.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatiotemporal dynamics of epileptiform propagations : imaging of human brain slices2011

    • Author(s)
      Kitaura H, et al.
    • Journal Title

      NeuroImage

      Volume: 58 Issue: 1 Pages: 50-59

    • DOI

      10.1016/j.neuroimage.2011.05.046

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Balloon cells in the dentate gyrus in hippocampal sclerosis associated with non-herpetic acute limbic encephalitis.2011

    • Author(s)
      Miyahara H, Ryufuku M, Fu YJ, Kitaura H, Murakami H, Masuda H, Kameyama S, Takahashi H, Kakita A
    • Journal Title

      Seizure

      Volume: 20 Issue: 1 Pages: 87-89

    • DOI

      10.1016/j.seizure.2010.09.013

    • Related Report
      2011 Annual Research Report 2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypertrophy of end folium neurons in patients with mesial temporal lobe epilepsy2011

    • Author(s)
      Ryufuku M, et al.
    • Journal Title

      Neuropathology

      Volume: 31 Issue: 5 Pages: 476-485

    • DOI

      10.1111/j.1440-1789.2010.01191.x

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypertrophy of hippocampal end folium neurons in patients with mesial temporal lobe epilepsy.2011

    • Author(s)
      Ryufuku M, Toyoshima Y, Kitaura H, et al.
    • Journal Title

      Neuropathology

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcranial imaging of somatotopic map plasticity after tail cut in mice.2010

    • Author(s)
      Kitaura H, Hishida R, Shibuki K
    • Journal Title

      Brain Res

      Volume: 1319 Pages: 54-59

    • DOI

      10.1016/j.brainres.2010.01.020

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transcranial imaging of somatotopic map plasticity after tail cut in mice.2010

    • Author(s)
      Kitaura H, et al.
    • Journal Title

      Brain Research

      Volume: 1319 Pages: 54-59

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Pathophysiological mechanisms underlying hippocampus sclerosis for MTLE : implications of flavoprotein fluorescence imaging on human brain slices2011

    • Author(s)
      H. Kitaura
    • Organizer
      Neuroscience 2011
    • Place of Presentation
      Washington DC,(米国)
    • Year and Date
      2011-11-14
    • Related Report
      2011 Final Research Report
  • [Presentation] Pathophysiological mechanisms undrlying hippocampal sclerosis for MTLE2011

    • Author(s)
      Kitaura H.
    • Organizer
      Society for Neruoscience
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-11-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 内側側頭葉てんかんにおける海馬硬化症の病態生理学的意義:ヒト脳スライス標本を用いたイメージング解析2011

    • Author(s)
      北浦弘樹
    • Organizer
      第45回日本てんかん学会
    • Place of Presentation
      朱鷺メッセ(新潟)
    • Year and Date
      2011-10-06
    • Related Report
      2011 Final Research Report
  • [Presentation] 内側側頭葉てんかんにおける海馬硬化の病態生理学的意義2011

    • Author(s)
      北浦弘樹
    • Organizer
      第45回日本てんかん学会
    • Place of Presentation
      新潟市
    • Year and Date
      2011-10-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] Spatiotemporal dynamics of epileptiform propagations in human partial epilepsy in vitro2010

    • Author(s)
      H. Kitaura
    • Organizer
      Neuroscience 2010
    • Place of Presentation
      San Diego,(米国)
    • Year and Date
      2010-11-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Spatiotemporal dynamics of epileptiform propagtationsin human partialepilepsy in vitro.2010

    • Author(s)
      Kitaura, et al.
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      サンディエゴ・米国
    • Year and Date
      2010-11-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新皮質てんかん病巣における興奮伝播様式の解析:ヒト脳スライス標本を用いた光学的イメージング2010

    • Author(s)
      北浦弘樹
    • Organizer
      第44回日本てんかん学会
    • Place of Presentation
      岡山コンベンションセンター
    • Year and Date
      2010-10-14
    • Related Report
      2011 Final Research Report
  • [Presentation] 新皮質てんかん病巣における興奮伝播様式の解析:ヒト脳スライス標本を用いた光学的イメージング2010

    • Author(s)
      北浦弘樹, et al.
    • Organizer
      第44回日本てんかん学会
    • Place of Presentation
      岡山
    • Year and Date
      2010-10-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] 二次性新皮質てんかんの興奮動態:ヒト脳スライス標本を用いた解析2010

    • Author(s)
      北浦弘樹
    • Organizer
      第51回日本神経病理学会総会
    • Place of Presentation
      シェーンバッハサボー(東京)
    • Year and Date
      2010-04-24
    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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