Clarification of epileptogenicity using human brain slices in vitro
| Project/Area Number |
22700376
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Research Collaborator |
KAKITA Akiyoshi 新潟大学, 脳研究所, 教授 (80281012)
FUKUDA Masafumi 新潟大学, 医歯学総合病院, 講師 (00361907)
KAMEYAMA Shigeki 国立病院機構, 西新潟中央病院, 院長
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | てんかん / イメージング / 電気生理 / フラビン蛍光 / 大脳皮質 / 急性スライス標本 / 光学的イメージング |
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| Research Abstract |
Epilepsy is one of the major neurological disorders in Japan. It is believed that hyper-excitability of the pyramidal neurons in the cerebral cortex contributes to epileptogenicity. However, the precise mechanism of the alteration was not still clarified. We struggled to observe spatiotemporal dynamics of epileptic activities using human brain slices taken from epileptic patients. As a result, we found unique epileptiform propagation of the activities in epileptogenic tissues but not in control tissues.
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Report
(3 results)
Research Products
(18 results)
