Relation between paracrine factors promoting adult neurogenesis and neurological diseases

• Project/Area Number: 22700385
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: KUWABARA Tomoko 独立行政法人産業技術総合研究所, 幹細胞工学研究センター, 研究員 (90358391)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 幹細胞 / 神経新生 / 神経 / うつ病 / 神経幹細胞 / 海馬 / 神経疾患 / ストレス

Research Abstract

We discovered a factor that causes the impairment of neurogenesis in the aged brain and in the brain under the neurological diseases. A mechanism has been identified by which stimuli including exercise re-activate the ability to generate newborn neurons.

Research Products

• [Journal Article] Regenerative medicine using adult neural stem cells : Potentials for diabetes therapy and other pharmaceutical applications (2012)
  • Author(s): Kuwabara T and Asashima M
  • Journal Title: J. Mol. Cell Biol. Volume: 4 Issue: 3 Pages: 133-139
  • DOI: 10.1093/jmcb/mjs016
  • Peer Reviewed
• [Journal Article] Olfactory bulb-derived neural stem cells of diabetes therapy (2012)
  • Author(s): Kuwabara T and Asashima M
  • Journal Title: Aroma Research Volume: 13 Pages: 31-35
  • URL: http://www.fujisan.co.jp/product/1281680951/b/756256/
  • Peer Reviewed
• [Journal Article] Prospects for regeneration therapy with stem cells (2012)
  • Author(s): Kuwabara T and Asashima M
  • Journal Title: Inflammation and Regeneration Volume: 32 Pages: 438-445
  • URL: http://jsir.gr.jp/journal/Vol32No1/contents.html
• [Journal Article] Active expression of retroelements in neurons differentiated from adult hippocampal neural stem cells (2012)
  • Author(s): Antoszczyk S, Terashima K, Warashina M, Asashima M, Kuwabara T
  • Journal Title: Neural Stem Cells and Therapy Volume: 11 Pages: 223-238
  • DOI: 10.5772/30105
  • ISBN: 9789533079585
  • Peer Reviewed
• [Journal Article] Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb (2011)
  • Author(s): Kuwabara T., Kagalwala M.N., Onuma Y., Ito Y., Warashina M., Terashima K., Sanosaka T., Nakashima K., Gage F.H., Asashima, M
  • Journal Title: EMBO Mol.Med. Volume: 3 Issue: 12 Pages: 742-754
  • DOI: 10.1002/emmm.201100177
  • Peer Reviewed
• [Journal Article] Reduction in paracrine Wnt3 factors during aging causes impaired adult neurogenesis (2011)
  • Author(s): Okamoto M, Inoue K, Iwamura H, Terashima K, Soya H: Asashima M, Kuwabara T
  • Journal Title: FASEB J Volume: 10 Issue: 10 Pages: 3570-3582
  • DOI: 10.1096/fj.11-184697
  • Peer Reviewed
• [Journal Article] Active expression of retroelements in neurons differentiated from adult hippocampal neural stem cells (2011)
  • Author(s): 桑原知子, 他
  • Journal Title: Neural Stem Cells (Intech) Volume: 1 Pages: 1-20
  • Peer Reviewed
• [Presentation] Environmental activation of retroelements during adult neurogenesis, Environment and Epigenetics (2012)
  • Author(s): Kuwabara T
  • Organizer: The 8th Okazaki Biology Conference
  • Place of Presentation: National Institute for Basic Biology, NIBB(愛知県)
  • Year and Date: 2012-03-25
• [Presentation] 海馬の神経新生とレトロトランスポゾン-環境への依存性と疾患との関わり- (2011)
  • Author(s): Kuwabara T
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2011-09-23
• [Presentation] 海馬の神経新生とレトロトランスポゾン-環境への依存性と疾患との関わり- (2011)
  • Author(s): Kuwabara T.
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館(京都府)(招待講演)
  • Year and Date: 2011-09-23
• [Presentation] Extrinsic Cues and Intracellular Epigenetic Regulations that Control Adult Neurogenesis (2011)
  • Author(s): Kuwabara T
  • Organizer: 日本神経科学会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-04
• [Presentation] Extrinsic Cues and Intracellular Epigenetic Regulations that Control Adult Neurogenesis (2011)
  • Author(s): Kuwabara T.
  • Organizer: 日本神経科学会
  • Place of Presentation: パシフィコ横浜(神奈川県)(招待講演)
  • Year and Date: 2011-09-04
• [Presentation] 自家幹細胞を用いた糖尿病の再生医療技術の開発 (2011)
  • Author(s): Kuwabara T
  • Organizer: LS-BT合同研究発表会
  • Place of Presentation: 産業技術総合研究所(茨城県)
  • Year and Date: 2011-01-31
• [Presentation] 自家幹細胞を用いた糖尿病の再生医療技術の開発 (2011)
  • Author(s): Kuwabara T.
  • Organizer: LS-BT合同研究発表会
  • Place of Presentation: 産業技術総合研究所(茨城県)(招待講演)
  • Year and Date: 2011-01-31
• [Presentation] 環境がレトロエレメントを介した成体の神経新生に与える影響 (2010)
  • Author(s): Kuwabara T
  • Organizer: 日本遺伝学会
  • Place of Presentation: 北海道大学(札幌)
  • Year and Date: 2010-09-20
• [Presentation] 環境がレトロエレメントを介した成体の神経新生に与える影響 (2010)
  • Author(s): 桑原知子
  • Organizer: 日本遺伝学会
  • Place of Presentation: 札幌、北海道大学
  • Year and Date: 2010-09-20
• [Remarks] (1) A Regenerative Therapy Method for Diabetes Using Adult Neural Stem Cells-Towards regenerative medicine transplanting patient's own stem cells to diseased parts-
  • URL: http://www.aist.go.jp/aist_e/latest_research/2011/20111215/20111215.html
• [Remarks] (2)桑原知子、浅島誠「成体の神経幹細胞を用いた、糖尿病の再生医療技術の開発」, 2011.10.08
  • URL: http://www.aist.go.jp/aist_j/press_release/pr2011/pr20111007/pr20111007.html
• [Remarks] (3) A Factor Regulating the Aging and Rejuvenation of the Brain-Discovery of an environmental factor for the activation of aged neural stem cells-
  • URL: http://www.aist.go.jp/aist_e/latest_research/2011/20110915/20110915.html
• [Remarks] (4)桑原知子、浅島誠「脳の「老化」と「若返り」を調節する因子.老化した神経幹細胞を活性化する環境因子の発見-」2011.8.8
  • URL: http://www.aist.go.jp/aist_j/new_research/nr20110808/nr20110808.html
• [Remarks]
  • URL: http://www.aist.go.jp/aist_j/new_research/nr20110808/nr20110808.html