Functional analysis of novel NYAP family proteins
| Project/Area Number |
22700391
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 神経細胞 / チロシンキナーゼ / PI3K / WAVE / シグナル伝達 / 神経科学 |
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| Research Abstract |
The phosphoinositide 3-kinase(PI3K) pathway has been extensively studied in neuronal function and morphogenesis. However, the precise molecular mechanisms of PI3K activation and its downstream signalling in neurons remain elusive. In this study, we demonstrated that the NYAPs bridge a PI3K-WAVE1 association by simultaneously interacting with PI3K and the WAVE1 complex. Disruption of the NYAP genes in mice affects brain size and neurite elongation.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] NMDAR2B tyrosine phosphorylation modulates anxiety-like behavior by regulating CRF expression2010
Author(s)
Delawary M, Tezuka T, Kiyama Y, Yokoyama K, Inoue T, Hattori S, Hashimoto R, Umemori H, Manabe T, Yamamoto T, Nakazawa T
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Journal Title
Mol. Brain
Volume: 3
Issue: 1
Pages: 37-37
DOI
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