| Project/Area Number |
22700393
|
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
|
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| Research Institution | Kagawa University (2011)
Tokyo Medical and Dental University (2010) |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | BDNF / コレステロール / ヒドロキシコレステロール / 神経細胞 / シナプス / 24HC / 脳由来神経栄養因子 / 代謝 / ホメオスタシス |
|---|
| Research Abstract |
Our previous study found that BDNF induced the synthesis of 24-hydroxycholesterol(24HC). However the roles of 24HC on CNS are not known. To better understand, we here investigate the effect of 24HC on primary neurons or astrocytes. The results indicated a possibility that, while 24HC was not involved in the BDNF-dependent effect on synapse development and dendritic morphology, 24HC did transduce the feedback signal to suppress the effect of BDNF.
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