The role of vascular formation in the central nervous system disease

• Project/Area Number: 22700395
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Osaka University
• Principal Investigator: MURAMATSU Rieko 大阪大学, 大学院・医学系研究科, 助教 (90536880)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 神経回路 / 軸索 / 血管 / 軸策 / 再生 / 多発性硬化症 / 接着因子

Research Abstract

Neovascularization has been considered beneficial in delaying the development of disease. In this study, we investigate the role of angiogenesis in wound hearing in the central nervous system(CNS) after injury. We found that some molecules from vascular endothelial cells promote neuronal development. This finding may contribute to develop therapy of CNS diseases.

Research Products

• [Presentation] 多発性硬化症における軸索再生阻害因子RGMの役割 (2012)
  • Author(s): 村松里衣子、山下俊英
  • Organizer: 第132回日本薬学会
  • Place of Presentation: 北海道大学(札幌)(招待講演)
  • Year and Date: 2012-03-29
• [Presentation] RGMa enhances T cell activation in autoimmune encephalomyelitis (2012)
  • Author(s): Rieko Muramatsu, Takekazu Kubo, Yuka Nakamura, Yuki Fujita, Toshihide Yamashita
  • Organizer: 第85回日本薬理学会
  • Place of Presentation: 京都国際会館(京都)
  • Year and Date: 2012-03-14
• [Presentation] Vascular endothelial cells promote cortical neurite elongation by a mechanism dependent on integrinβ3 (2011)
  • Author(s): Satoko Sumimoto, Rieko Muramatsu, Sakiko Fujii, Toshihide Yamashita
  • Organizer: Neuro2011
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-15
• [Presentation] RGMa modulates T cell responses and is involved in autoimmune encephalomyelitis (2011)
  • Author(s): Rieko Muramatsu, Takekazu Kubo, Masahiro Mori, Yuka Nakamura, Yuki Fujita, Satoshi Kuwabara, Toshihide Yamashita
  • Organizer: Neuro2011
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2011-09-15
• [Presentation] Vascular endothelial cells promote cortical neurite elongation by a mechanism dependent on integrin β 3 (2011)
  • Author(s): Satoko Sumimoto, Rieko Muramatsu, Sakiko Fujii, Toshihide Yamashita
  • Organizer: Neuro2011
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2011-09-15
• [Presentation] 中枢神経傷害後に形成する新生血管による神経回路再生の促進 (2010)
  • Author(s): 村松里衣子、山下俊英
  • Organizer: 第18回日本血管生物医学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-02
• [Presentation] Neovessel promotes axonal reorganization in the experimental autoimmune encephalomyelitis mice. (2010)
  • Author(s): Muramatsu, R., Yamashita, T.
  • Organizer: Neuro2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-05
• [Presentation] 血管新生が導く神経回路修復 (2010)
  • Author(s): 村松里衣子、山下俊英
  • Organizer: 2010年度 包括脳ネットワーク夏のワークショップ
  • Place of Presentation: 札幌
  • Year and Date: 2010-07-28
• [Presentation] 血管内皮細胞の接着性因子による神経突起伸長の促進 (2010)
  • Author(s): 住本知子、村松里衣子、藤井早紀子、山下俊英
  • Organizer: 第25回神経組織の成長・再生・移植研究会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2010-05-22
• [Presentation] 血管,免疫と脳の相互作用 (2010)
  • Author(s): 村松里衣子
  • Organizer: 神経化学の若手研究者育成セミナー
  • Place of Presentation: 兵庫(招待講演)
• [Book] 脳21 (2011)
  • Author(s): 村松里衣子、山下俊英
  • Total Pages: 4
  • Publisher: 金芳堂
• [Book] ライフサイエンス新着論文レビュー (2011)
  • Author(s): 村松里衣子、山下俊英
  • Publisher: (電子ジャーナル)