Psychiatric dysfunction regulated by NADPH oxidase

• Project/Area Number: 22700397
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: IBI Masakazu 京都府立医科大学, 医学研究科, 助教 (10336539)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: NADPHオキシダーゼ / 活性酸素種 / 精神障害 / 不安様行動 / うつ様行動 / BDNF / 不安行動 / HPA axis

Research Abstract

The involvement of reactive oxygen species(ROS) in anxiety and mood disorders has been reported ; however, the source of ROS in the nervous system has not been identified. NADPH oxidase is a superoxide-generating enzyme composed of multiple subunits including a membrane-spanning catalytic subunit, NOX. ROS derived from NOX1/NADPH oxidase, which possess a newly identified catalytic subunit, appear to play a key role in stress-induced anxiety and depressive-like behaviors, possibly by regulating activation of the hypothalamic-pituitary-adrenal axis and decrease in BDNF level.

Research Products

• [Journal Article] Involvement of NOX1/NADPH oxidase in morphine-induced analgesia and tolerance (2011)
  • Author(s): Ibi M, Matsuno K, Matsumoto M, Sasaki M, Nakagawa T, Katsuyama M, Iwata K, Zhang J, Kaneko S, Yabe-Nishimura C.
  • Journal Title: Journal of Neuroscience Volume: 31 Issue: 49 Pages: 18094-18103
  • DOI: 10.1523/jneurosci.4136-11.2011
  • Peer Reviewed
• [Journal Article] A Seven-Transmembrane Receptor That Mediates Avoidance Response to Dihydrocaffeic Acid, a Water-Soluble Repellent in Caenorhabditis elegans (2011)
  • Author(s): Aoki, R., Yagami, T., Sasakura, H., Ogura, K.I., Kajihara, Y., Ibi, M., Miyamae, T., Nakamura, F., Asakura, T., Kanai, Y., et al.
  • Journal Title: J Neurosci Volume: 31 Issue: 46 Pages: 16603-16610
  • DOI: 10.1523/jneurosci.4018-11.2011
  • Peer Reviewed
• [Journal Article] NOX1/nicotinamide adenine dinucleotide phosphate, reduced form(NADPH) oxidase promotes proliferation of stellate cells and aggravates liver fibrosis induced by bile duct ligation (2011)
  • Author(s): Cui W, Matsuno K, iwata K Ibi M, Matsumoto M, Zhang J, Zhu K, Katsuyama M, Torok NJ, Yabe-Nishimura C
  • Journal Title: Hepatology Volume: 54 Issue: 3 Pages: 949-958
  • DOI: 10.1002/hep.24465
  • Peer Reviewed
• [Journal Article] Sp3 transcription factor is crucial for transcriptional activation of the human NOX4 gene (2011)
  • Author(s): Katsuyama M, Hirai H, Iwata K, Ibi M, Matsuno K, Matsumoto M, Yabe-Nishimura C
  • Journal Title: FEBS J Volume: 278 Issue: 6 Pages: 964-972
  • DOI: 10.1111/j.1742-4658.2011.08018.x
  • Peer Reviewed
• [Presentation] NOX1/NADPH oxidaseはモルヒネの鎮痛作用と耐性形成に関与する (2012)
  • Author(s): 衣斐督和、松野邦晴、松本みさき、矢部千尋
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 京都
  • Year and Date: 2012-03-15
• [Presentation] NOX1/NADPH oxidaseはモルヒネの鎮痛作用と耐性形成に関与する (2012)
  • Author(s): 衣斐督和
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 京都国際会議場(京都府)
  • Year and Date: 2012-03-15
• [Presentation] ストレスにより誘発される不安・うつ様行動におけるNOX1/NADPH oxidaseの役割 (2011)
  • Author(s): 衣斐督和、松野邦晴、内牧弘祐、矢部千尋
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-17
• [Presentation] ストレスにより誘発される不安・うつ様行動におけるNOX1/NADPH oxidaseの役割 (2011)
  • Author(s): 衣斐督和
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-17
• [Presentation] NOX1/NADPH oxidaseはHPA axisの活性化を介して拘束ストレスによる不安を増強する (2011)
  • Author(s): 内牧弘祐、衣斐督和、松野邦晴、矢部千尋
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-22
• [Presentation] NOX1/NADPH oxidaseはHPA axisの活性化を介して拘束ストレスによる不安を増強する
  • Author(s): 内牧弘祐, ら
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: (誌面発表)
• [Book] 生体内におけるNADPHオキシダーゼ (2012)
  • Author(s): 衣斐督和
  • Publisher: ファルマシア
• [Remarks]
  • URL: http://www.f.kpu-m.ac.jp/k/pharmaco/gyoseki.html
• [Remarks]
  • URL: http://www.f.kpu-m.ac.jp/k/pharmaco/gyoseki.html
• [Remarks]
  • URL: http://www.f.kpu-m.ac.jp/k/pharmaco/index.html