Psychiatric dysfunction regulated by NADPH oxidase
| Project/Area Number |
22700397
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
IBI Masakazu 京都府立医科大学, 医学研究科, 助教 (10336539)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | NADPHオキシダーゼ / 活性酸素種 / 精神障害 / 不安様行動 / うつ様行動 / BDNF / 不安行動 / HPA axis |
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| Research Abstract |
The involvement of reactive oxygen species(ROS) in anxiety and mood disorders has been reported ; however, the source of ROS in the nervous system has not been identified. NADPH oxidase is a superoxide-generating enzyme composed of multiple subunits including a membrane-spanning catalytic subunit, NOX. ROS derived from NOX1/NADPH oxidase, which possess a newly identified catalytic subunit, appear to play a key role in stress-induced anxiety and depressive-like behaviors, possibly by regulating activation of the hypothalamic-pituitary-adrenal axis and decrease in BDNF level.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] A Seven-Transmembrane Receptor That Mediates Avoidance Response to Dihydrocaffeic Acid, a Water-Soluble Repellent in Caenorhabditis elegans2011
Author(s)
Aoki, R., Yagami, T., Sasakura, H., Ogura, K.I., Kajihara, Y., Ibi, M., Miyamae, T., Nakamura, F., Asakura, T., Kanai, Y., et al.
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Journal Title
J Neurosci
Volume: 31
Issue: 46
Pages: 16603-16610
DOI
Related Report
Peer Reviewed
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