Analyses of N-terminal processing of secretory lectin PAP-III in neuronal regeneration
| Project/Area Number |
22700398
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Nagoya University (2011)
Osaka City University (2010) |
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Principal Investigator |
KONISHI Hiroyuki 名古屋大学, 大学院・医学系研究科, 助教 (90448746)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | グリア細胞 / 神経再生 / 再生医学 / 神経科学 / 脳・神経 / 細胞・組織 / 糖鎖 |
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| Research Abstract |
I revealed that N-terminal processed PAP-III(ΔN-PAP-III) formed fibrillar structures and attached tightly to neuronal surfaces. When a dense networks ofΔN-PAP-III fibers were prepared on the culture dishes, neurites preferentially adhere to theΔN-PAP-III fibers and neurite extension was enhanced. These results suggest a possibility that PAP-III may form insoluble fibrillar structures around injury site and would provide regenerating axons with a platform for elongation.
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Report
(3 results)
Research Products
(20 results)
