| Project/Area Number |
22700401
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
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|---|
| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 幹細胞生物学 / 再生 / 修復 / コンドロイチン硫酸 / 神経再生 / 細胞接着 / シグナル伝達機構 / 神経幹細胞 / 細胞周期 / 細胞内情報伝達 |
|---|
| Research Abstract |
Chondroitin sulfate(CS) is an important component of the cell surface and extracellular matrix in the central nervous system. CS is divided into at least four subclasses, known as CS-A, CS-C, CS-D and CS-E, on the basis of the sulfation patterns of their major disaccharide units. The CS-E polysaccharide, but not CS-A, CS-C or CS-D polysaccharide, was changed cell adhesion and mourphology of cultured neuronal cells. The action of CS-E polysaccharide is mediated through VEGF receptor/eNOS and VEGF receptor/Raf-1/Rb signalings.
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