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Sulfation patterns and molecular mechanisms of Chondroitin sulfate polysaccharide in regulating the neuronal regeneration

Research Project

Project/Area Number 22700401
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neurochemistry/Neuropharmacology
Research InstitutionKurume University

Principal Investigator

SOTOGAKU Naoki  久留米大学, 医学部, 講師 (60368884)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords幹細胞生物学 / 再生 / 修復 / コンドロイチン硫酸 / 神経再生 / 細胞接着 / シグナル伝達機構 / 神経幹細胞 / 細胞周期 / 細胞内情報伝達
Research Abstract

Chondroitin sulfate(CS) is an important component of the cell surface and extracellular matrix in the central nervous system. CS is divided into at least four subclasses, known as CS-A, CS-C, CS-D and CS-E, on the basis of the sulfation patterns of their major disaccharide units. The CS-E polysaccharide, but not CS-A, CS-C or CS-D polysaccharide, was changed cell adhesion and mourphology of cultured neuronal cells. The action of CS-E polysaccharide is mediated through VEGF receptor/eNOS and VEGF receptor/Raf-1/Rb signalings.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (3 results)

All 2011 Other

All Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Book] ストレス科学事典(日本ストレス学会、パブリックヘルスリサーチセンター監修、分担執筆)2011

    • Author(s)
      外角直樹
    • Publisher
      実務教育出版
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.kurume-u.ac.jp/med/phram/index.html

    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] うつ病治療のための併用剤2011

    • Inventor(s)
      西昭徳、外角直樹、首藤隆秀、黒岩真帆美、宮川剛、小林克典、Paul Greengard
    • Industrial Property Rights Holder
      西昭徳
    • Filing Date
      2011-04-20
    • Related Report
      2011 Final Research Report
    • Overseas

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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