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Screening and functional screening of the genes which regulate the proliferation of Muller glia in damaged retina.

Research Project

Project/Area Number 22700403
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neurochemistry/Neuropharmacology
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

SUGA Akiko  独立行政法人理化学研究所, 網膜再生医療研究開発プロジェクト, 研究員 (70450400)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords網膜 / ミュラーグリア細胞 / 前駆細胞 / 再生 / 神経 / ミュラーグリア / 細胞増殖 / マウス系統 / 神経幹細胞
Research Abstract

In this research, we showed that the degree of proliferation of Muller glia after retinal damage was significantly less in B6 mice compared to other mouse strains. Furthermore, addition of GSK3 inhibitor did not affect the proliferation of Muller glia in the damaged retina from B6 mice, whereas GSK3 inhibitor significantly increased the number of proliferative Muller glia in other mouse strains. By comparing the genome-wide gene expression in retinas after damage between B6 and other mouse strain, we found that the expression patterns of chromosome remodeling factors and components of innate immune system were different associating with the proliferation of Muller glia.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (9 results)

All 2013 2012 2011 2010

All Journal Article (2 results) Presentation (4 results) Book (2 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] 網膜再生とwnt シグナル2010

    • Author(s)
      須賀晶子、高橋政代
    • Journal Title

      医学の歩み

      Volume: 233巻10号 Pages: 1037-1043

    • Related Report
      2012 Final Research Report
  • [Journal Article] 網膜再生とwntシグナル2010

    • Author(s)
      須賀晶子
    • Journal Title

      医学の歩み

      Volume: 233 Pages: 1037-1043

    • Related Report
      2010 Annual Research Report
  • [Presentation] Genetic difference in the proliferation of Muller glia after retinal damage in adult mouse2012

    • Author(s)
      Suga A, Sadamoto K, Fujii M, and Takahashi M.
    • Organizer
      ISSCR (International Society for Stem Cell Research) 10^<th> Annual Meeting
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] Genetic difference in the proliferation of Müller glia after retinal damage in adult mouse2012

    • Author(s)
      Suga A, Sadamoto K, Fujii M, and Takahashi M
    • Organizer
      ISSCR (International Society for Stem Cell Research) 10th Annual Meeting
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] Genetic influence on Muller glial cell proliferation after retinal damage in adult mouse2011

    • Author(s)
      Suga A, Sadamoto K, and Takahashi M.
    • Organizer
      Stem Cells in Development and Disease 2011
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2012 Final Research Report
  • [Presentation] Genetic influence on Muller glial cell proliferation after retinal damage in adult mouse2011

    • Author(s)
      須賀晶子
    • Organizer
      Stem Cells in Development and Disease 2011
    • Place of Presentation
      Max Delbruck Centrum fur Molekulare Medizin,ドイツ、ベルリン
    • Related Report
      2011 Annual Research Report
  • [Book] 網膜の幹細胞 再生医療叢書 4 巻2013

    • Author(s)
      須賀晶子
    • Related Report
      2012 Final Research Report
  • [Book] 再生医療叢書 4巻 上皮・感覚器 網膜の幹細胞2013

    • Author(s)
      須賀晶子
    • Total Pages
      232
    • Publisher
      朝倉書店
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 細胞膜透過性ダンベル型rna およびその製造方法2011

    • Inventor(s)
      阿部洋 , 伊藤嘉浩, 阿部奈保子, 烏田美和子, 中嶋裕子, 須賀晶子, 高橋政代
    • Industrial Property Rights Holder
      独立行政法人理化学研究所
    • Filing Date
      2011-03-11
    • Related Report
      2012 Final Research Report
    • Overseas

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Published: 2010-08-23   Modified: 2019-07-29  

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