| Project/Area Number |
22700404
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurochemistry/Neuropharmacology
|
|---|
| Research Institution | The Institute of Physical and Chemical Research |
|---|
Principal Investigator |
WATANABE Shoji 独立行政法人理化学研究所, 運動ニューロン変性研究チーム, 研究員 (80462745)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | p47 / TDP-43 / ALS / タンパク質の安定性 / タンパク質局在化機構 / タンパク質安定性 |
|---|
| Research Abstract |
TDP-43 is one of a causative protein of amyotrophic lateral sclerosis(ALS), and generally related with the ALS pathology. The mechanism of motor neuron degeneration by TDP-43, however, is still unknown.
The representative of this study(I) identified p47 as a novel protein interacted with TDP-43.I elucidated that p47 interacts with not ALS-linked TDP-43 mutant proteins but wild-type. In addition, I clarified that the half-life of ALS-linked mutant TDP-43 protein is longer than that of wild-type. Early onset of ALS correlates with increased stability of familial ALS-linked mutant TDP-43 proteins.
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