Analysis of inhibitory interneuron subtypes with distinct subcellular domain innervation to projection neurons in the mouse olfactory bulb

• Project/Area Number: 22700409
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Neurophysiology and muscle physiology
• Research Institution: The University of Tokyo
• Principal Investigator: NARITSUKA Hiromi 東京大学, 大学院・医学系研究科, 特任研究員 (00511388)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 嗅球 / 抑制性介在ニューロン / 成体神経新生 / 顆粒細胞 / 樹状突起 / スパイン

Research Abstract

Previous studies of neuronal circuits in the rodent olfactory bulb focused mainly on the interplay between projection neurons and dendritic-targeting inhibitory interneurons. In this study, in addition to the dendritic-targeting subtype, we studied the perisomatic-targeting subtype of inhibitory interneurons to identify the functional differentiation of these subtypes to elucidate the information processing in the olfactory bulb. We found that granule cells show subtype specific electrophysiological properties, timing of cell generation and sensory input-dependent morphological changes.

Research Products

• [Journal Article] 5T4 Glycoprotein regulates the sensory input-dependent development of a specific subtype of newborn interneurons in the mouse olfactory bulb (2012)
  • Author(s): Yoshihara S, Takahashi H, Nishimura N, Naritsuka H, Shirao T, Hirai H, Yoshihara Y, Mori K, Stern P. L. and Tsuboi A
  • Journal Title: The Journal of Neuroscience Volume: Vol.32 Issue: 6 Pages: 2217-2226
  • DOI: 10.1523/jneurosci.5907-11.2012
  • Peer Reviewed
• [Journal Article] Characterization of nestin expression in the spinal cord of GFP transgenic mice after peripheral nerve injury. (2010)
  • Author(s): Matsumura S, Takagi K, Okuda-Ashitaka E, Lu J, Naritsuka H, Yamaguchi M and Ito S
  • Journal Title: Neuroscience Volume: 170 Issue: 3 Pages: 942-953
  • DOI: 10.1016/j.neuroscience.2010.07.034
  • Peer Reviewed
• [Journal Article] Tbr2 Deficiency in Mitral and Tufted Cells Disrupts Excitatory-Inhibitory Balance of Neural Circuitry in the Mouse Olfactory Bulb
  • Author(s): Mizuguchi R, Naritsuka H, Mori K, Yoshihara Y
  • Journal Title: Journal of Neuroscience Volume: (掲載確定印刷中)
  • Peer Reviewed
• [Presentation] Synaptic connection of adult-born interneurons to distinct subcellular domains of projection neurons in the mouse olfactory bulb (2011)
  • Author(s): Hiromi Naritsuka, Kensaku Mori, Masahiro Yamaguchi
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-16