Control of neural circuit formation using light-regulated adenylyl cyclase in vivo.
| Project/Area Number |
22700410
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ISHII Tomohiro 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (60549947)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 神経科学 / 脳・神経 / 発生・分化 / シグナル伝達 / 遺伝学 / 神経回路 / 嗅覚 / マウス発生工学 / 発生分化 / オプトジェネティクス |
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| Research Abstract |
To understand how cAMP is used to exert various functions in mouse olfactory sensory neurons(OSNs), we generated transgenic mice in which PAC, photo-activated adenylate cyclase, is expressed under the control of the mouse olfactory receptor promoter. PAC was detected throughout OSN including dendrites and axons, allowing local activation of PAC. We are currently analyzing the function of cAMP in neural circuit formation by regulating PAC activity using light.
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Report
(3 results)
Research Products
(4 results)
