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Control of neural circuit formation using light-regulated adenylyl cyclase in vivo.

Research Project

Project/Area Number 22700410
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neurophysiology and muscle physiology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

ISHII Tomohiro  東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (60549947)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords神経科学 / 脳・神経 / 発生・分化 / シグナル伝達 / 遺伝学 / 神経回路 / 嗅覚 / マウス発生工学 / 発生分化 / オプトジェネティクス
Research Abstract

To understand how cAMP is used to exert various functions in mouse olfactory sensory neurons(OSNs), we generated transgenic mice in which PAC, photo-activated adenylate cyclase, is expressed under the control of the mouse olfactory receptor promoter. PAC was detected throughout OSN including dendrites and axons, allowing local activation of PAC. We are currently analyzing the function of cAMP in neural circuit formation by regulating PAC activity using light.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (4 results)

All 2012 2011 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 2 results)

  • [Journal Article] Coordinated coexpression of two vomeronasal receptor V2R genes per neuron in the mouse2011

    • Author(s)
      Ishii T, Mombaerts P
    • Journal Title

      Mol Cell Neurosci

      Volume: 46 Pages: 397-408

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/cbio/index.html

    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] ポリペプチド、単離された核酸、組み換えベクター、遺伝子導入キット、形質転換体、および細胞内カルシウムシグナルの調整方法2012

    • Inventor(s)
      石井智浩、中田隆夫
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Filing Date
      2012-02-16
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] ポリペプチド、単離された核酸、組み換えベクター、遺伝子導入キット、形質転換体、および細胞内カルシウムシグナルの調整方法2012

    • Inventor(s)
      石井智浩、中田隆夫
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Filing Date
      2012-02-16
    • Related Report
      2011 Annual Research Report
    • Overseas

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Published: 2010-08-23   Modified: 2016-04-21  

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