Characterization of synaptic inputs to cerebellar globular cells
| Project/Area Number |
22700423
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
HIRONO Moritoshi 独立行政法人理化学研究所, 運動学習制御研究チーム, 研究員 (30318836)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 小脳 / グロビュラー細胞 / ルガロ細胞 / プルキンエ細胞 / 抑制性介在ニューロン / 苔状線維 / セロトニン / 抑制性シナプス後電流 |
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| Research Abstract |
Cerebellar globular cells, a subgroup of Lugaro cells, have been identified morphologically. By using whole-cell patch-clamp recordings we found that globular cells received prominent IPSCs together with monosynaptic inputs from the axon collaterals of Purkinje cells. Additionally, globular cells likely received excitatory monosynaptic inputs through mossy fibers. Globular cells appear to integrate input and output signals of the cerebellar cortex.
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Report
(3 results)
Research Products
(21 results)
