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Development of bidirectional brain-machine interface using electrocorticogram to restore motor functions of arms for paralyzed patients

Research Project

Project/Area Number 22700435
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Fusional brain recording science
Research InstitutionOsaka University

Principal Investigator

YANAGISAWA Takufumi  大阪大学, 医学系・研究科, 特任研究員 (90533802)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Keywordsブレインマシーンインターフェイス / Brain-machine interface / 感覚フィードバック / 皮質脳波 / 上肢運動機能再建 / 電動義手 / Brain-machlne interface
Research Abstract

In this study, we have developed a bidirectional brain-machine interface to operate a prosthetic arm with tactile sensor using the electrocorticogram(ECoG) recorded by the electrodes implanted on human sensorimotor cortices. Some severely paralyzed patients due to stroke or trauma were shown to be able to operate the prosthetic arm only using their ECoG signals by imaging some movements of their paralyzed limbs. The patients operated the prosthetic arm to manipulate some objects by grasping and releasing. Furthermore, we have developed a prosthetic arm to be controlled by signals of magnetoencephalogram(MEG).

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (38 results)

All 2012 2011 2010 Other

All Journal Article (14 results) (of which Peer Reviewed: 5 results) Presentation (17 results) Book (2 results) Remarks (2 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 3 results)

  • [Journal Article] Electrocorticographic control of a prosthetic arm in paralyzed patients2012

    • Author(s)
      Yanagisawa T, Hirata M, Saitoh Y, Kishima H, Matsushita K, Goto T, Fukuma R, Yokoi H, Kamitani Y, Yoshimine T
    • Journal Title

      Annals of Neurology

      Volume: 71(3) Pages: 353-61

    • Related Report
      2011 Final Research Report
  • [Journal Article] Movement-related neuromagnetic fields and performances of single trial classifications2012

    • Author(s)
      Sugata H, Goto T, Hirata M, Yanagisawa T, Shayne M, Matsushita K, Yoshimine T, Yorifuji S
    • Journal Title

      Neuroreport

      Volume: 23(1) Pages: 16-20

    • Related Report
      2011 Final Research Report
  • [Journal Article] Motor restoration based on the brain machine interface using brain surface electrodes : real time robot control and a fully-implantable wireless system2012

    • Author(s)
      Hirata Masayuki
    • Journal Title

      Advanced robotics

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 麻痺患者における感覚運動野皮質脳波の変化とBMIへの応用2012

    • Author(s)
      柳澤琢史
    • Journal Title

      認知神経科学

      Volume: (In press)

    • NAID

      10031136830

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 麻痺患者における感覚運動野皮質脳波の変化とBMIへの応用2012

    • Author(s)
      柳澤琢史
    • Journal Title

      機能的脳神経外科

      Volume: (In press)

    • NAID

      10031136830

    • Related Report
      2011 Annual Research Report
  • [Journal Article] A fully-implantable wireless system for human brain-machine interfaces using brain surface electrodes : W-HERBS2011

    • Author(s)
      Hirata M, Matsushita K, Suzuki T, Yoshida T, Sato F, Morris S, Yanagisawa T, Goto T, Kawato M, Yoshimine T
    • Journal Title

      IEICE Trans Commun

      Volume: E94-B(9) Pages: 2448-2453

    • NAID

      10030187415

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Real-time control of a prosthetic hand using human electrocorticography signals2011

    • Author(s)
      Yanagisawa T, Hirata M, Saitoh Y, Goto T, Kishima H, Fukuma R, Yokoi H, Kamitani Y, Yoshimine T
    • Journal Title

      J Neurosurg

      Volume: 114(6) Pages: 1715-22

    • Related Report
      2011 Final Research Report
  • [Journal Article] Electrocorticographic control of a prosthetic arm in paralyzed patients2011

    • Author(s)
      Yanagisawa T
    • Journal Title

      Ann Neurol.

      Volume: 4(Epub ahead of print) Issue: 3 Pages: 353-361

    • DOI

      10.1002/ana.22613

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Real-time control of a prosthetic hand using human electrocorticograms2011

    • Author(s)
      Yanagisawa T
    • Journal Title

      Journal of neurosurgery

      Volume: 114(6) Issue: 6 Pages: 1715-1722

    • DOI

      10.3171/2011.1.jns101421

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Movement-related neuromagnetic fields and performances of single trial classifications2011

    • Author(s)
      Sugata Hisato
    • Journal Title

      Neuroreport

      Volume: 23(1) Issue: 1 Pages: 16-20

    • DOI

      10.1097/wnr.0b013e32834d935a

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脳表電極を用いたブレイン・マシン・インターフェースの展望2011

    • Author(s)
      平田雅之
    • Journal Title

      ヒューマンインターフェース学会誌

      Volume: 13(3) Pages: 131-136

    • Related Report
      2011 Annual Research Report
  • [Journal Article] ブレイン・マシン・インターフェイスに対する(ALS)患者さんの全国版意識調査2011

    • Author(s)
      影山悠
    • Journal Title

      日本ALS協会会報

      Volume: 84 Pages: 62-62

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Training-free control of robot by BMI using physiological characteristics of ECoG2010

    • Author(s)
      Takufumi Yanagisawa
    • Journal Title

      Functional neurosurgery

      Volume: 49 Pages: 162-165

    • NAID

      10029745550

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Motor restoration based on the brain machine interface using brain surface electrodes : real time robot control and a fully-implantable wireless system

    • Author(s)
      Hirata M, Matsushita K, Yanagisawa T, Goto T, Morris S, Yokoi H, Suzuki T, Yoshida T, Sato F, Sakura O, Kamitani Y, Yoshimine T
    • Journal Title

      Advanced robotics

      Volume: (in press)

    • NAID

      10031135707

    • Related Report
      2011 Final Research Report
  • [Presentation] Gamma amplitude coupled with alpha phase represents motor2011

    • Author(s)
      Takufumi Yanagisawa
    • Organizer
      Society for neuroscience
    • Place of Presentation
      Washington DC convention center, USA
    • Year and Date
      2011-11-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Gamma amplitude coupled with alpha phase represents motor information before actual movements2011

    • Author(s)
      Takufumi Yanagisawa
    • Organizer
      Society for neuroscience 2011
    • Place of Presentation
      ワシントンDC、アメリカ
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] BMIによるロボットアーム制御と脳損傷後皮質脳波変化の定量的解析2011

    • Author(s)
      柳澤琢史
    • Organizer
      認知神経科学会学術集会
    • Place of Presentation
      産業医科大学、福岡
    • Year and Date
      2011-10-23
    • Related Report
      2011 Final Research Report
  • [Presentation] BMIによるロボットアーム制御と脳損傷後皮質脳波変化の定量的解析2011

    • Author(s)
      柳澤琢史
    • Organizer
      認知神経科学会学術集会
    • Place of Presentation
      産業医科大学(福岡)(招待講演)
    • Year and Date
      2011-10-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脳損傷後の皮質脳波変化の定量的解析とBMIへの応用2011

    • Author(s)
      柳澤琢史
    • Organizer
      日本脳神経外科学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-10-14
    • Related Report
      2011 Final Research Report
  • [Presentation] 脳損傷後の皮質脳波変化の定量的解析とBMIへの応用2011

    • Author(s)
      柳澤琢史
    • Organizer
      日本脳神経外科学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2011-10-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Gamma amplitude coupled with alpha phase represents motor2011

    • Author(s)
      柳澤琢史
    • Organizer
      日本神経科学学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-09-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Gamma amplitude coupled with alpha phase represents motor information before actual movements2011

    • Author(s)
      Takufumi Yanagisawa
    • Organizer
      日本神経科学学会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 麻痺患者における感覚運動野皮質脳波の変化とBMIへの応用2011

    • Author(s)
      柳澤琢史
    • Organizer
      第50回日本定位・機能神経外科学会
    • Place of Presentation
      広島
    • Year and Date
      2011-01-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 麻痺患者における感覚運動野皮質脳波の変化とBMIへの応用2011

    • Author(s)
      柳澤琢史
    • Organizer
      第50回 日本定位・機能神経外科学会
    • Place of Presentation
      ANAクラウンホテル広島
    • Year and Date
      2011-01-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Prosthetic arm control by paralyzed patients using neural decoding of their electrocorticograms2010

    • Author(s)
      Takufumi Yanagisawa
    • Organizer
      Society for Neuroscience 2010
    • Place of Presentation
      Sandiego, USA
    • Year and Date
      2010-11-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Prosthetic arm control by paralyzed patients using neural decoding of their electrocorticograms2010

    • Author(s)
      Takufumi Yanagisawa
    • Organizer
      Society for neuroscience
    • Place of Presentation
      San diego, USA
    • Year and Date
      2010-11-13
    • Related Report
      2011 Final Research Report
  • [Presentation] 皮質脳波BMIを用いた麻痺患者の運動機能再建2010

    • Author(s)
      柳澤琢史
    • Organizer
      日本脳神経外科学会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2010-10-29
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Real-time and training-free control of a prosthetic arm using human2010

    • Author(s)
      Takufumi Yanagisawa
    • Organizer
      29^<th> ICCN
    • Place of Presentation
      Kobe
    • Year and Date
      2010-10-28
    • Related Report
      2011 Final Research Report
  • [Presentation] Real-time and training-free control of a prosthetic arm using human electrocortlcograms2010

    • Author(s)
      Takufumi Yanagisawa
    • Organizer
      29th International congress of clinical neurophysiology (ICCN2010) (Kobe)
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Prosthetic arm control by paralyzed patients using EGoG signals2010

    • Author(s)
      Takufumi Yanagisawa
    • Organizer
      Neuro2010
    • Place of Presentation
      Kobe
    • Year and Date
      2010-09-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Prosthetic arm control by paralyzed patients using electrocorticograms2010

    • Author(s)
      Takufumi Yanagisawa
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Book] 皮質脳波を用いたBMIによる運動機能再建、先端医療シリーズ40リハ医とコメディカルのための最新リハビリテーション医学2010

    • Author(s)
      柳澤琢史平田雅之吉峰俊樹
    • Related Report
      2011 Final Research Report
  • [Book] 先端医療シリーズ40リハ医とコメディカルのための最新リハビリテーション医学2010

    • Author(s)
      柳澤琢史、平田雅之、吉峰俊樹
    • Publisher
      寺田国際事務所/先端医療技術研究所
    • Related Report
      2010 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.nsurg.med.osaka-u.ac.jp/school/research/research.html#c16

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.nsurg.med.osaka-u.ac.jp/school/research/research.html#c16

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 体内埋込装置のケーシングと体内埋込装置、および体内埋込装置のケーシングの製造方法、および体内埋込装置を用いた治療支援方法2011

    • Inventor(s)
      平田雅之、吉峰俊樹、松下光次郎、後藤哲、柳澤琢史、鈴木隆文、吉村眞一
    • Industrial Property Rights Holder
      平田雅之、吉峰俊樹、松下光次郎、後藤哲、柳澤琢史、鈴木隆文、吉村眞一
    • Filing Date
      2011-03-10
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] MACHINE CONTROL DEVICE, MACHINE SYSTEM, MACHINE CONTROL METHOD, AND RECORDING MEDIUM STORING MACHINE CONTROL PROGRAM2010

    • Inventor(s)
      Hirata M, Yanagisawa T, Kamitani Y, Yokoi H, Yoshimine T, Goto T, Fukuma R, Kato R
    • Industrial Property Rights Holder
      Hirata M, Yanagisawa T, Kamitani Y, Yokoi H, Yoshimine T, Goto T, Fukuma R, Kato R
    • Filing Date
      2010-05-03
    • Related Report
      2011 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] MACHINE CONTROL DEVICE, MACHINE SYSTEM, MACHINE CONTROL METHOD, AND RECORDING MEDIUM STORING MACHINE CONTROL PROGRAM2010

    • Inventor(s)
      Masayuki Hirata, Takufumi Yanagisawa, Yukiyasu Kamitani, Hiroshi Yokoi, Toshiki Yoshimine, Tetsu Goto, Ryohei Fukuma, Ryu Kato
    • Industrial Property Rights Holder
      Masayuki Hirata, Takufumi Yanagisawa, Yukiyasu Kamitani, Hiroshi Yokoi, Toshiki Yoshimine, Tetsu Goto, Ryohei Fukuma, Ryu Kato
    • Filing Date
      2010-05-03
    • Related Report
      2010 Annual Research Report
    • Overseas

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Published: 2010-08-23   Modified: 2016-04-21  

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