Development of bidirectional brain-machine interface using electrocorticogram to restore motor functions of arms for paralyzed patients

• Project/Area Number: 22700435
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Fusional brain recording science
• Research Institution: Osaka University
• Principal Investigator: YANAGISAWA Takufumi 大阪大学, 医学系・研究科, 特任研究員 (90533802)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2010: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
• Keywords: ブレインマシーンインターフェイス / Brain-machine interface / 感覚フィードバック / 皮質脳波 / 上肢運動機能再建 / 電動義手 / Brain-machlne interface

Research Abstract

In this study, we have developed a bidirectional brain-machine interface to operate a prosthetic arm with tactile sensor using the electrocorticogram(ECoG) recorded by the electrodes implanted on human sensorimotor cortices. Some severely paralyzed patients due to stroke or trauma were shown to be able to operate the prosthetic arm only using their ECoG signals by imaging some movements of their paralyzed limbs. The patients operated the prosthetic arm to manipulate some objects by grasping and releasing. Furthermore, we have developed a prosthetic arm to be controlled by signals of magnetoencephalogram(MEG).

Research Products

• [Journal Article] Electrocorticographic control of a prosthetic arm in paralyzed patients (2012)
  • Author(s): Yanagisawa T, Hirata M, Saitoh Y, Kishima H, Matsushita K, Goto T, Fukuma R, Yokoi H, Kamitani Y, Yoshimine T
  • Journal Title: Annals of Neurology Volume: 71(3) Pages: 353-61
• [Journal Article] Movement-related neuromagnetic fields and performances of single trial classifications (2012)
  • Author(s): Sugata H, Goto T, Hirata M, Yanagisawa T, Shayne M, Matsushita K, Yoshimine T, Yorifuji S
  • Journal Title: Neuroreport Volume: 23(1) Pages: 16-20
• [Journal Article] Motor restoration based on the brain machine interface using brain surface electrodes : real time robot control and a fully-implantable wireless system (2012)
  • Author(s): Hirata Masayuki
  • Journal Title: Advanced robotics Volume: (In press)
  • Peer Reviewed
• [Journal Article] 麻痺患者における感覚運動野皮質脳波の変化とBMIへの応用 (2012)
  • Author(s): 柳澤琢史
  • Journal Title: 認知神経科学 Volume: (In press)
  • NAID: 10031136830
• [Journal Article] 麻痺患者における感覚運動野皮質脳波の変化とBMIへの応用 (2012)
  • Author(s): 柳澤琢史
  • Journal Title: 機能的脳神経外科 Volume: (In press)
  • NAID: 10031136830
• [Journal Article] A fully-implantable wireless system for human brain-machine interfaces using brain surface electrodes : W-HERBS (2011)
  • Author(s): Hirata M, Matsushita K, Suzuki T, Yoshida T, Sato F, Morris S, Yanagisawa T, Goto T, Kawato M, Yoshimine T
  • Journal Title: IEICE Trans Commun Volume: E94-B(9) Pages: 2448-2453
  • NAID: 10030187415
• [Journal Article] Real-time control of a prosthetic hand using human electrocorticography signals (2011)
  • Author(s): Yanagisawa T, Hirata M, Saitoh Y, Goto T, Kishima H, Fukuma R, Yokoi H, Kamitani Y, Yoshimine T
  • Journal Title: J Neurosurg Volume: 114(6) Pages: 1715-22
• [Journal Article] Electrocorticographic control of a prosthetic arm in paralyzed patients (2011)
  • Author(s): Yanagisawa T
  • Journal Title: Ann Neurol. Volume: 4(Epub ahead of print) Issue: 3 Pages: 353-361
  • DOI: 10.1002/ana.22613
  • Peer Reviewed
• [Journal Article] Real-time control of a prosthetic hand using human electrocorticograms (2011)
  • Author(s): Yanagisawa T
  • Journal Title: Journal of neurosurgery Volume: 114(6) Issue: 6 Pages: 1715-1722
  • DOI: 10.3171/2011.1.jns101421
  • Peer Reviewed
• [Journal Article] Movement-related neuromagnetic fields and performances of single trial classifications (2011)
  • Author(s): Sugata Hisato
  • Journal Title: Neuroreport Volume: 23(1) Issue: 1 Pages: 16-20
  • DOI: 10.1097/wnr.0b013e32834d935a
  • Peer Reviewed
• [Journal Article] 脳表電極を用いたブレイン・マシン・インターフェースの展望 (2011)
  • Author(s): 平田雅之
  • Journal Title: ヒューマンインターフェース学会誌 Volume: 13(3) Pages: 131-136
• [Journal Article] ブレイン・マシン・インターフェイスに対する(ALS)患者さんの全国版意識調査 (2011)
  • Author(s): 影山悠
  • Journal Title: 日本ALS協会会報 Volume: 84 Pages: 62-62
• [Journal Article] Training-free control of robot by BMI using physiological characteristics of ECoG (2010)
  • Author(s): Takufumi Yanagisawa
  • Journal Title: Functional neurosurgery Volume: 49 Pages: 162-165
  • NAID: 10029745550
  • Peer Reviewed
• [Journal Article] Motor restoration based on the brain machine interface using brain surface electrodes : real time robot control and a fully-implantable wireless system
  • Author(s): Hirata M, Matsushita K, Yanagisawa T, Goto T, Morris S, Yokoi H, Suzuki T, Yoshida T, Sato F, Sakura O, Kamitani Y, Yoshimine T
  • Journal Title: Advanced robotics Volume: (in press)
  • NAID: 10031135707
• [Presentation] Gamma amplitude coupled with alpha phase represents motor (2011)
  • Author(s): Takufumi Yanagisawa
  • Organizer: Society for neuroscience
  • Place of Presentation: Washington DC convention center, USA
  • Year and Date: 2011-11-12
• [Presentation] Gamma amplitude coupled with alpha phase represents motor information before actual movements (2011)
  • Author(s): Takufumi Yanagisawa
  • Organizer: Society for neuroscience 2011
  • Place of Presentation: ワシントンDC、アメリカ
  • Year and Date: 2011-11-12
• [Presentation] BMIによるロボットアーム制御と脳損傷後皮質脳波変化の定量的解析 (2011)
  • Author(s): 柳澤琢史
  • Organizer: 認知神経科学会学術集会
  • Place of Presentation: 産業医科大学、福岡
  • Year and Date: 2011-10-23
• [Presentation] BMIによるロボットアーム制御と脳損傷後皮質脳波変化の定量的解析 (2011)
  • Author(s): 柳澤琢史
  • Organizer: 認知神経科学会学術集会
  • Place of Presentation: 産業医科大学(福岡)(招待講演)
  • Year and Date: 2011-10-23
• [Presentation] 脳損傷後の皮質脳波変化の定量的解析とBMIへの応用 (2011)
  • Author(s): 柳澤琢史
  • Organizer: 日本脳神経外科学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-10-14
• [Presentation] 脳損傷後の皮質脳波変化の定量的解析とBMIへの応用 (2011)
  • Author(s): 柳澤琢史
  • Organizer: 日本脳神経外科学会総会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2011-10-14
• [Presentation] Gamma amplitude coupled with alpha phase represents motor (2011)
  • Author(s): 柳澤琢史
  • Organizer: 日本神経科学学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-09-17
• [Presentation] Gamma amplitude coupled with alpha phase represents motor information before actual movements (2011)
  • Author(s): Takufumi Yanagisawa
  • Organizer: 日本神経科学学会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2011-09-17
• [Presentation] 麻痺患者における感覚運動野皮質脳波の変化とBMIへの応用 (2011)
  • Author(s): 柳澤琢史
  • Organizer: 第50回日本定位・機能神経外科学会
  • Place of Presentation: 広島
  • Year and Date: 2011-01-22
• [Presentation] 麻痺患者における感覚運動野皮質脳波の変化とBMIへの応用 (2011)
  • Author(s): 柳澤琢史
  • Organizer: 第50回 日本定位・機能神経外科学会
  • Place of Presentation: ANAクラウンホテル広島
  • Year and Date: 2011-01-22
• [Presentation] Prosthetic arm control by paralyzed patients using neural decoding of their electrocorticograms (2010)
  • Author(s): Takufumi Yanagisawa
  • Organizer: Society for Neuroscience 2010
  • Place of Presentation: Sandiego, USA
  • Year and Date: 2010-11-18
• [Presentation] Prosthetic arm control by paralyzed patients using neural decoding of their electrocorticograms (2010)
  • Author(s): Takufumi Yanagisawa
  • Organizer: Society for neuroscience
  • Place of Presentation: San diego, USA
  • Year and Date: 2010-11-13
• [Presentation] 皮質脳波BMIを用いた麻痺患者の運動機能再建 (2010)
  • Author(s): 柳澤琢史
  • Organizer: 日本脳神経外科学会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2010-10-29
• [Presentation] Real-time and training-free control of a prosthetic arm using human (2010)
  • Author(s): Takufumi Yanagisawa
  • Organizer: 29^<th> ICCN
  • Place of Presentation: Kobe
  • Year and Date: 2010-10-28
• [Presentation] Real-time and training-free control of a prosthetic arm using human electrocortlcograms (2010)
  • Author(s): Takufumi Yanagisawa
  • Organizer: 29th International congress of clinical neurophysiology (ICCN2010) (Kobe)
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-10-28
• [Presentation] Prosthetic arm control by paralyzed patients using EGoG signals (2010)
  • Author(s): Takufumi Yanagisawa
  • Organizer: Neuro2010
  • Place of Presentation: Kobe
  • Year and Date: 2010-09-03
• [Presentation] Prosthetic arm control by paralyzed patients using electrocorticograms (2010)
  • Author(s): Takufumi Yanagisawa
  • Organizer: Neuro2010
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-09-03
• [Book] 皮質脳波を用いたBMIによる運動機能再建、先端医療シリーズ40リハ医とコメディカルのための最新リハビリテーション医学 (2010)
  • Author(s): 柳澤琢史平田雅之吉峰俊樹
• [Book] 先端医療シリーズ40リハ医とコメディカルのための最新リハビリテーション医学 (2010)
  • Author(s): 柳澤琢史、平田雅之、吉峰俊樹
  • Publisher: 寺田国際事務所/先端医療技術研究所
• [Remarks] ホームページ
  • URL: http://www.nsurg.med.osaka-u.ac.jp/school/research/research.html#c16
• [Remarks]
  • URL: http://www.nsurg.med.osaka-u.ac.jp/school/research/research.html#c16
• [Patent(Industrial Property Rights)] 体内埋込装置のケーシングと体内埋込装置、および体内埋込装置のケーシングの製造方法、および体内埋込装置を用いた治療支援方法 (2011)
  • Inventor(s): 平田雅之、吉峰俊樹、松下光次郎、後藤哲、柳澤琢史、鈴木隆文、吉村眞一
  • Industrial Property Rights Holder: 平田雅之、吉峰俊樹、松下光次郎、後藤哲、柳澤琢史、鈴木隆文、吉村眞一
  • Filing Date: 2011-03-10
  • Overseas
• [Patent(Industrial Property Rights)] MACHINE CONTROL DEVICE, MACHINE SYSTEM, MACHINE CONTROL METHOD, AND RECORDING MEDIUM STORING MACHINE CONTROL PROGRAM (2010)
  • Inventor(s): Hirata M, Yanagisawa T, Kamitani Y, Yokoi H, Yoshimine T, Goto T, Fukuma R, Kato R
  • Industrial Property Rights Holder: Hirata M, Yanagisawa T, Kamitani Y, Yokoi H, Yoshimine T, Goto T, Fukuma R, Kato R
  • Filing Date: 2010-05-03
  • Overseas
• [Patent(Industrial Property Rights)] MACHINE CONTROL DEVICE, MACHINE SYSTEM, MACHINE CONTROL METHOD, AND RECORDING MEDIUM STORING MACHINE CONTROL PROGRAM (2010)
  • Inventor(s): Masayuki Hirata, Takufumi Yanagisawa, Yukiyasu Kamitani, Hiroshi Yokoi, Toshiki Yoshimine, Tetsu Goto, Ryohei Fukuma, Ryu Kato
  • Industrial Property Rights Holder: Masayuki Hirata, Takufumi Yanagisawa, Yukiyasu Kamitani, Hiroshi Yokoi, Toshiki Yoshimine, Tetsu Goto, Ryohei Fukuma, Ryu Kato
  • Filing Date: 2010-05-03
  • Overseas