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Facilitation of motor learning by non-invasive brain stimulation

Research Project

Project/Area Number 22700442
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Fusional brain recording science
Research InstitutionNational Institute for Physiological Sciences

Principal Investigator

TANAKA Satoshi  生理学研究所, 大脳皮質機能研究系, 特任助教 (10545867)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords脳機能操作 / 非侵襲脳機能計測 / 学習 / 記憶 / 脳卒中 / リハビリテーション / 電気刺激 / 脳刺激 / 経頭蓋直流電気刺激 / 磁気刺激
Research Abstract

Transcranial direct current stimulation(tDCS) is a non-invasive procedure of cortical stimulation, where weak direct currents polarize the target brain regions(Tanaka and Watanabe, 2009). In the present project, I have demonstrated that anodal tDCS over the lower limb motor cortex can transiently enhance the maximal force of the lower extremities in both healthy participants and subcortical stroke patients(Tanaka et al., 2011). Physiologically, it has been believed that tDCS modulated the brain activity only in the stimulated cortical region. However, my study has shown that tDCS modulated the brain activities not only in the stimulated cortical region but also in the subcortical region in both human and rat animal model. Further understanding of behavioral and physiological effects of tDCS will be relevant for the clinical application of tDCS.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (15 results)

All 2011 2010 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (6 results) Remarks (2 results)

  • [Journal Article] Single session of transcranial direct-current stimulation transiently increases knee extensor force in patients with hemiparetic stroke2011

    • Author(s)
      Tanaka S, Takeda K, Otaka Y, Kita K, Osu R, Honda M, Sadato N, Hanakawa T and Watanabe K
    • Journal Title

      Neurorehabilitation and Neural Repair

      Volume: 25 Pages: 565-569

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of motor learning and memory formation by non-invasive cortical stimulation of the primary motor cortex2011

    • Author(s)
      Tanaka S, Sandrini M and Cohen LG
    • Journal Title

      Neuropsychological Rehabilitation

      Volume: 21(5) Pages: 650-675

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 脳卒中後の認知・運動障害に対する経頭蓋直流電気刺激法の効果2011

    • Author(s)
      田中悟志・菅原翔・定藤規弘
    • Journal Title

      臨床神経生理学

      Volume: 39 Pages: 219-226

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Single session of transcranial direct-current stimulation transiently increases knee extensor force in patients with hemiparetic stroke2011

    • Author(s)
      Tanaka S, Takeda K, Otaka Y, Kita K, Osu R, Honda M, Sadato N, Hanakawa T, Watanabe K
    • Journal Title

      Neurorehabil Neural Repair

      Volume: 25 Issue: 6 Pages: 565-569

    • DOI

      10.1177/1545968311402091

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modulation of motor learning and memory formation by non-invasive cortical stimulation of the primary motor cortex2011

    • Author(s)
      Tanaka S, Sandrini M, Cohen LG
    • Journal Title

      Neuropsychological Rehabilitation

      Volume: 21 Issue: 5 Pages: 650-675

    • DOI

      10.1080/09602011.2011.605589

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脳卒中後の認知・運動機能障害に対する経頭蓋直流電気刺激の効果2011

    • Author(s)
      田中悟志、菅原翔、定藤規弘
    • Journal Title

      臨床神経生理学雑誌

      Volume: 39 Pages: 219-226

    • NAID

      10029429057

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single session of transcranial direct-current stimulation transiently increases kneeextensor force in patients with hemiparetic stroke2011

    • Author(s)
      Tanaka S, Takeda K, Otaka Y, Kita K, Osu R, Honda M, Sadato N, Hanakawa T, Watanabe K
    • Journal Title

      Neurorehabilitation and Neural Repair

      Volume: (印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Social praise enhances the off-line improvement of the procedural motor skill. Society for Neuroscience2011

    • Author(s)
      Sugawara S, Tanaka S, Okazaki S, Watanabe K, Sadato N
    • Organizer
      41st Annual Meeting, Washington DC
    • Place of Presentation
      USA
    • Year and Date
      2011-11-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 経頭蓋直流電気刺激による慢性期脳卒中患者の下肢筋力増強2011

    • Author(s)
      田中悟志・武田湖太郎・大高洋平・北佳保里・大須理英子・花川隆・渡邊克巳
    • Organizer
      第四十回日本臨床神経生理学会,神戸ポートピアホテル
    • Place of Presentation
      兵庫県
    • Year and Date
      2011-11-01
    • Related Report
      2011 Final Research Report
  • [Presentation] 経頭蓋直流電気刺激による慢性期脳卒中患者の下肢筋力増強2011

    • Author(s)
      田中悟志・武田湖太郎・大高洋平・北佳保里・大須理英子・花川隆・渡邊克巳
    • Organizer
      第四十回日本臨床神経生理学会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2011-11-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Non-invasive cortical stimulation enhances lower limb function in chronic stroke patients2011

    • Author(s)
      Tanaka S, Takeda K, Otaka Y, Kita K, Osu R, Honda M, Sadato N, Hanakawa T, Watanabe K
    • Organizer
      14th European Congress on Clinical Neurophysiology
    • Place of Presentation
      Rome, ITALY
    • Year and Date
      2011-06-22
    • Related Report
      2011 Final Research Report
  • [Presentation] Non-invasive cortical stimulation enhances lower limb function in chronic stroke patients2011

    • Author(s)
      Tanaka S, Takeda K, Otaka Y, Kita K, Osu R, Honda M, Sadato N, Hanakawa T, Watanabe K
    • Organizer
      14th European Congress on Clinical Neurophysiology
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2011-06-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 経頭蓋直流電気刺激による慢性期脳卒中患者の下肢筋力増強2010

    • Author(s)
      田中悟志・武田湖太郎・大高洋平・北佳保里・大須理英子・花川隆・渡邊克巳
    • Organizer
      第四十回日本臨床神経生理学会
    • Place of Presentation
      神戸国際会議場(兵庫)
    • Year and Date
      2010-11-01
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://researchmap.jp/tanakasatoshi

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.nips.ac.jp/contents/release/entry/2011/06/post-179.html

    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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