| Project/Area Number |
22700448
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
|
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| Research Institution | Shinshu University |
|---|
Principal Investigator |
KAKUTA Shigeru 信州大学, ヒト環境科学研究支援センター, 助教 (80345032)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 疾患モデル / 大腸がん / サイトカイン / IL-17 / IL-1 |
|---|
| Research Abstract |
To elucidate the role of pro-inflammatory cytokines, IL-1/IL-17 family members, in development of intestinal polyps, the molecular mechanisms were analyzed using ApcMin mice, as a model of colon cancer. We found that deficiency of IL-17A and/or IL-17F in ApcMin mice caused suppression of intestinal polyp formation, and administration of neutralizing antibodies against IL-17A and/or IL-17F reduced development of polyps. These results suggest that endogenous IL-17A/F promote polyp formation and neutralizing antibodies are applied to therapeutic agent for colon cancer.
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