Analysis of IL-1/IL-17 system-dependent promoting mechanisms for development of colon cancer using model mice
| Project/Area Number |
22700448
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Laboratory animal science
|
|---|
| Research Institution | Shinshu University |
|---|
Principal Investigator |
KAKUTA Shigeru 信州大学, ヒト環境科学研究支援センター, 助教 (80345032)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 疾患モデル / 大腸がん / サイトカイン / IL-17 / IL-1 |
|---|
| Research Abstract |
To elucidate the role of pro-inflammatory cytokines, IL-1/IL-17 family members, in development of intestinal polyps, the molecular mechanisms were analyzed using ApcMin mice, as a model of colon cancer. We found that deficiency of IL-17A and/or IL-17F in ApcMin mice caused suppression of intestinal polyp formation, and administration of neutralizing antibodies against IL-17A and/or IL-17F reduced development of polyps. These results suggest that endogenous IL-17A/F promote polyp formation and neutralizing antibodies are applied to therapeutic agent for colon cancer.
|
Report
(3 results)
Research Products
(41 results)
-
-
-
-
-
-
-
-
[Journal Article] TNF, but Not IL-6 and IL-17, Is Crucial for the Development of T Cell-Independent Psoriasis-Like Dermatitis in Il1rn-/-Mice2010
Author(s)
Nakajima A, Matsuki T, Komine M, Asahina A, Horai R, Nakae S, Ishigame H, Kakuta S, Saijo S, and Iwakura Y
-
Journal Title
J Immunol
Volume: 185
Issue: 3
Pages: 1887-1893
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
