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Development of infertility treatment model using infertile mice and iPS cells

Research Project

Project/Area Number 22700454
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Laboratory animal science
Research InstitutionOsaka University

Principal Investigator

ISOTANI Ayako  大阪大学, 微生物病研究所, 助教 (20444523)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords生殖細胞 / 不妊 / 疾患モデル / iPS細胞 / 疾患モデル動物
Research Abstract

Infertility treatment for patients with germ cell loss does not exist at all. In this study, we attempt to develop a germ cell loss treatment model using a XXY type mouse which has the sex chromosome abnormality as Klinefelter' s syndrome model. First, in order to regenerate the germ cells, we attempted the establishment of induced pluripotent stem cell(iPS). Some iPS cell-like lines were able to establish. However, the foreign gene could not be removed from iPS cell-like lines. As a result, the regeneration of germ cells did not reach.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (8 results)

All 2011 2010

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (5 results)

  • [Journal Article] Formation of a thymus from rat ES cells in xenogeneic nude mouse<--> rat ES chimeras2011

    • Author(s)
      Isotani A., et al
    • Journal Title

      Genes Cells

      Volume: 16 Issue: 4 Pages: 397-405

    • DOI

      10.1111/j.1365-2443.2011.01495.x

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A homozygous mutant embryonic stem cell bank applicable for phenotype-driven genetic screening2011

    • Author(s)
      Horie K.
    • Journal Title

      Nature Methods

      Volume: 8 Issue: 12 Pages: 1071-1077

    • DOI

      10.1038/nmeth.1739

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Formation of a thymus from rat ES cells in xenogeneic nude mouse〓rat ES chimeras.2011

    • Author(s)
      Isotani A, Hatayama H, Kaseda K, Ikawa M, Okabe M.
    • Journal Title

      Genes to Cells

      Volume: (未定 印刷中)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 異種キメラ動物を使ってES細胞から臓器をつくる2011

    • Author(s)
      磯谷綾子、畑山英、かせ田一宏、伊川正人、岡部勝
    • Organizer
      第58回日本実験動物学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-25
    • Related Report
      2011 Final Research Report
  • [Presentation] 異種キメラ動物を使ってES細胞から臓器をつくる2011

    • Author(s)
      磯谷綾子
    • Organizer
      第58回日本実験動物学会総会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2011-05-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] A trial to form an organ from ES cells-a rat thymus in rat-nude mouse chimera-2011

    • Author(s)
      磯谷綾子、畑山英、かせ田一宏、伊川正人、岡部勝
    • Organizer
      平成22年度研究業績発表会
    • Place of Presentation
      大阪
    • Year and Date
      2011-01-21
    • Related Report
      2011 Final Research Report
  • [Presentation] マウス←ラットキメラを用いた臓器形成モデルの確立2010

    • Author(s)
      磯谷綾子、畑山英、かせ田一宏、伊川正人、岡部勝
    • Organizer
      第33回日本分子生物学会年会、第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-16
    • Related Report
      2011 Final Research Report
  • [Presentation] マウス←ラットキメラを用いた臓器形成モデルの確立2010

    • Author(s)
      磯谷綾子
    • Organizer
      第32回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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