| Project/Area Number |
22700454
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory animal science
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| Research Institution | Osaka University |
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Principal Investigator |
ISOTANI Ayako 大阪大学, 微生物病研究所, 助教 (20444523)
|
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 生殖細胞 / 不妊 / 疾患モデル / iPS細胞 / 疾患モデル動物 |
|---|
| Research Abstract |
Infertility treatment for patients with germ cell loss does not exist at all. In this study, we attempt to develop a germ cell loss treatment model using a XXY type mouse which has the sex chromosome abnormality as Klinefelter' s syndrome model. First, in order to regenerate the germ cells, we attempted the establishment of induced pluripotent stem cell(iPS). Some iPS cell-like lines were able to establish. However, the foreign gene could not be removed from iPS cell-like lines. As a result, the regeneration of germ cells did not reach.
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