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Establishment of producing method for detection antibody for primate using DNA immunization technology

Research Project

Project/Area Number 22700455
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Laboratory animal science
Research InstitutionOsaka University

Principal Investigator

TOUGAN Takahiro  大阪大学, 微生物病研究所, 助教 (20379093)

Co-Investigator(Renkei-kenkyūsha) HORII Toshihiro  大阪大学, 微生物病研究所, 教授 (80142305)
YASUTOMI Yasuhiro  独立行政法人医薬基盤研究所, 霊長類医科学研究センター, センター長 (90281724)
TACIBANA Taro  大阪市立大学, 工学(系)研究科(研究院), 准教授 (80311752)
NKAMURA Shota  大阪大学, 微生物病研究所, 助教 (90432434)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsリスザル / モデル動物 / 免疫関連遺伝子 / イムノグロブリン / Fcγレセプター / 検出抗体 / 次世代シークエンサー / マラリア / Fcgレセプター / 熱帯熱マラリア / 霊長類 / 検出用抗体 / IgG / cDNAライブラリー / 遺伝子クローニング / モノクローナル抗体
Research Abstract

The squirrel monkey (Saimiri sciureus) is a valuable experimental animal for research into infectious diseases such as malaria vaccine development; however, the IgG molecules in this animal are not yet to be characterized. Antibody-dependent cellular cytotoxity is an antibody-mediated immune response and is important for exclusion of pathogens or cancer cells. In human, IgG1 or IgG3 interacts with the Fc receptor, FcγRIIIa. Previous studies have revealed that human FcγRIIIa contains a substitution (Phe→Val) at residue 176 that can interact with IgG4 in addition to IgG1 and IgG3. Here we show that the squirrel monkey IgG interacts with its FcγRIIIa. Finally, highly sensitive and specific anti-squirrel monkey IgG monoclonal antibodies were developed for used in western blotting and ELISA assays.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (61 results)

All 2013 2012 2011 2010 Other

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (29 results) Book (15 results) Remarks (3 results)

  • [Journal Article] Endemic Burkitt lymphoma is associated with strength and diversity of Plasmodium falciparummalaria stage-specific antigen antibody response2013

    • Author(s)
      Aka P, Vila MC, Jariwala A, Nkrumah F, Emmanuel B, Yagi M, Palacpac NM, Periago MV, Neequaye J, Kiruthu C, Tougan T, Levine PH, Biggar RJ, Pfeiffer RM, Bhatia K, Horii T, Bethony JM, Mbulaiteye SM
    • Journal Title

      Blood

      Volume: 122(5) Issue: 5 Pages: 629-635

    • DOI

      10.1182/blood-2012-12-475665

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Within-population genetic diversity of Plasmodium falciparum vaccine candidate antigens reveals geographic distance from a Central sub-Saharan African origin.2013

    • Author(s)
      Tanabe K., Mita T., Palacpac N., Arisue N., Tougan T., Kawai S.,Jombart T., Kobayashi F., Horii T.
    • Journal Title

      Vaccine

      Volume: 31 Issue: 9 Pages: 1334-9

    • DOI

      10.1016/j.vaccine.2012.12.039

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] TLR9 adjuvants enhance immunogenicity and protective efficacy of the SE36/AHG malaria vaccine in nonhuman primate models2013

    • Author(s)
      Tougan T, Aoshi T, Coban C, Katakai Y, Kai C, Yasutomi Y, Ishii KJ, Horii T
    • Journal Title

      Hum Vaccin Immunother

      Volume: 9(2) Issue: 2 Pages: 283-290

    • DOI

      10.4161/hv.22950

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasmodium cynomolgi genome sequences provide insight into Plasmodium vivax and the monkey malaria clade.2012

    • Author(s)
      Tachibana S, Mita T.
    • Journal Title

      Nature Genet

      Volume: 44 Issue: 9 Pages: 1051-5

    • DOI

      10.1038/ng.2375

    • NAID

      120006985529

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Transcutaneous immunization using a dissolving microneedle array protects against tetanus, diphtheria, malaria, and influenza2012

    • Author(s)
      Matsuo K, Hirobe S, Yokota Y, Ayabe Y, Seto M, Quan YS, Kamiyama F, Tougan T, Horii T, Mukai Y, Okada N, Nakagawa S
    • Journal Title

      J Control Release

      Volume: 160(3) Issue: 3 Pages: 495-501

    • DOI

      10.1016/j.jconrel.2012.04.001

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Geographic differentiation of polymorphism in the Plasmodium falciparum malaria vaccine candidate gene SERA52012

    • Author(s)
      Tanabe K, Arisue N, 他12名
    • Journal Title

      Vaccine

      Volume: 30 Issue: 9 Pages: 1583-1593

    • DOI

      10.1016/j.vaccine.2011.12.124

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antibodies reactive to Plasmodium falciparum serine repeat antigen in children with burkitt lymphoma from ghana2012

    • Author(s)
      Guech-Ongey M, Yagi M, Palacpac NM, Emmanuel B, Talisuna AO, Bhatia K, Cristina Stefan D, Biggar RJ, Nkrumah F, Neequaye J, Tougan T, Horii T, Mbulaiteye SM
    • Journal Title

      Int J Cancer

      Volume: 130(8) Issue: 8 Pages: 1908-14

    • DOI

      10.1002/ijc.26203

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Mek1 phosphorylation cascade plays a role in meiotic recombination of Schizosaccharomyces pombe2010

    • Author(s)
      Tougan T, Kasama T, Ohtaka A, Okuzaki D, Saito TT, Russell P, Nojima H
    • Journal Title

      Cell Cycle

      Volume: 9(23) Issue: 23 Pages: 4688-4702

    • DOI

      10.4161/cc.9.23.14050

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] GenopalTM: a novel hollow fiber array for focused microarray analysis2010

    • Author(s)
      Okuzaki D, Fukushima T, Tougan T, Ishii T, Kobayashi S, Akita T, Nojima H
    • Journal Title

      DNA Research

      Volume: 17(6) Issue: 6 Pages: 369-379

    • DOI

      10.1093/dnares/dsq025

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evidences of protection against blood-stage infection of Plasmodium falciparum by the novel protein vaccine SE362010

    • Author(s)
      Horii T, Shirai H, Jie L, Ishii KJ, Palacpac NQ, Tougan T, Hato M, Ohta N, Bobogare A, Arakaki N, Matsumoto Y, Namazue J, Ishikawa T, Ueda S, Takahashi M
    • Journal Title

      Parasitology Int

      Volume: 59(3) Issue: 3 Pages: 380-386

    • DOI

      10.1016/j.parint.2010.05.002

    • NAID

      10029825230

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasmacytoid dendritic cells delineate immunogenicity of influenza vaccine subtypes2010

    • Author(s)
      Koyama S, Aoshi T, Tanimoto T, Kumagai Y, Kobiyama K, Tougan T, Sakurai K, Coban C, Horii T, Akira S, Ishii KJ
    • Journal Title

      Sci Transl Med

      Volume: 2 Issue: 25 Pages: 24-25

    • DOI

      10.1126/scitranslmed.3000759

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evidences of protection against blood-stage infection of Plasmodium falciparum by the novel protein vaccine SE36.2010

    • Author(s)
      Horii T, Shirai H, Jie L, Ishii KJ, Palacpac NQ, Tougan T, Hato M, Ohta N, Bobogare A, Arakaki N, Matsumoto Y, Namazue J, Ishikawa T, Ueda S, Takahashi M.
    • Journal Title

      Parasitology International

      Volume: 59 Pages: 380-386

    • NAID

      10029825230

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genopal^<TM> : a novel hollow fiber array for focused microarray analysis.2010

    • Author(s)
      Okuzaki D, Fukushima T, Tougan T, Ishii T, Kobayashi S, Akita T, Nojima H.
    • Journal Title

      DNA Research

      Volume: 17 Pages: 369-379

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Mek1 phosphorylation cascade plays a role in meiotic recombination of Schizosaccharomyces pombe.2010

    • Author(s)
      Tougan T, Kasama T, Ohtaka A, Okuzaki D, Saito TT, Russell P, Nojima H.
    • Journal Title

      Cell Cycle

      Volume: 9 Pages: 4688-4702

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 抗 SE36 抗体の誘導とマラリア抵抗性に関与する遺伝的バックグラウンドの研究/Analysis of African HLA genes in a population that participated in the Phase 1b trial of BK-SE362013

    • Author(s)
      東岸任弘、Nirianne Q. Palacpac、八木正典、中村昇太、後藤和義、Thomas G. Egwang、堀井俊宏
    • Organizer
      第82回日本寄生虫学会大会
    • Place of Presentation
      東京医科歯科大学湯島キャンパス(東京)
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規アジュバントを添加した次世代SE36 マラリアワクチンの開発:旅行者用ワクチンへのアプローチ2013

    • Author(s)
      東岸任弘、青枝大貴、Cevayir Coban、片貝祐子、甲斐知恵子、保富康宏、石井健、堀井俊宏
    • Organizer
      日本薬学会第133回年会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Related Report
      2012 Final Research Report
  • [Presentation] 抗 SE36 抗体の誘導とマラリア抵抗性に関与する遺伝的バックグラウンドの研究2013

    • Author(s)
      東岸任弘、Nirianne Q. Palacpac、八木正典、中村昇太、後藤和義、Thomas G. Egwang、堀井俊宏
    • Organizer
      感染症若手フォーラム 2013
    • Place of Presentation
      北広島クラッセホテル(北海道)
    • Related Report
      2012 Final Research Report
  • [Presentation] 抗SE36抗体の誘導とマラリア抵抗性に関与する遺伝的バックグラウンドの研究2013

    • Author(s)
      東岸任弘、Nirianne Q. Palacpac、八木正典、中村昇太、後藤和義、Thomas G. Egwang、堀井俊宏
    • Organizer
      感染症若手フォーラム 2013
    • Place of Presentation
      北広島クラッセホテル(北海道)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新規アジュバント添加による次世代 SE36 マラリアワクチンの開発と実用化:旅行者用ワクチンへのアプローチ2012

    • Author(s)
      東岸任弘、青枝大貴、八木正典、有末伸子、片貝祐子、保富康宏、甲斐知恵子、石井健、堀井俊宏
    • Organizer
      日本実験動物技術者協会北陸支部 本部共催講習会第331回
    • Place of Presentation
      金沢大学学際科学実験センター(石川)
    • Year and Date
      2012-03-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規アジュバント添加による次世代SE36マラリアワクチンの開発と実用化:旅行者用ワクチンへのアプローチ2012

    • Author(s)
      東岸任弘、青枝大貴、八木正典、有末伸子、片貝祐子、保富康宏、甲斐知恵子、石井健、堀井俊宏
    • Organizer
      日本実験動物技術者協会北陸支部本部共催講習会第331回
    • Place of Presentation
      金沢大学学際科学実験センター(石川)(招待講演)
    • Year and Date
      2012-03-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] リスザルは1種類のIgGしか持たず、サブクラスを持たない2012

    • Author(s)
      東岸任弘、中村昇太、朴辰幸、片貝祐子、保富康宏、立花太郎、堀井俊宏
    • Organizer
      感染症若手フォーラム
    • Place of Presentation
      「やすらぎ伊王島」海の見えるホテル(長崎)
    • Year and Date
      2012-02-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] リスザルは単一の IgG を持ち、サブクラスを持たない2012

    • Author(s)
      東岸任弘、中村昇太、朴辰幸、片貝祐子、保富康宏、立花太郎、堀井俊宏
    • Organizer
      日本実験動物科学・技術 九州 2012
    • Place of Presentation
      ビーコンプラザ(大分)
    • Related Report
      2012 Final Research Report
  • [Presentation] ホテル阪急エキスポパーク(大阪)2012

    • Author(s)
      東岸任弘、中村昇太、朴辰幸、片貝祐子、保富康宏、立花太郎、堀井俊宏
    • Organizer
      NGS 現場の会 第2回研究会
    • Place of Presentation
      ホテル阪急エキスポパーク(大阪)
    • Related Report
      2012 Final Research Report
  • [Presentation] Squirrel monkey has a single IgG and no IgG subclasses2012

    • Author(s)
      Takahiro Tougan, Shota Nakamura, Chin-Heng Paku, Yuko Katakai, Yasuhiro Yasutomi, Taro Tachibana and Toshihiro Horii
    • Organizer
      5th International CVRDC-RIMD Joint Symposium
    • Place of Presentation
      SEOGWIPO KAL HOTEL(韓国・済州島)
    • Related Report
      2012 Final Research Report
  • [Presentation] ・リスザルは単一の IgG を持ち2012

    • Author(s)
      東岸任弘、中村昇太、朴辰幸、片貝祐子、保富康宏、立花太郎、堀井俊宏
    • Organizer
      日本分子生物学会 第12回 春季シンポジウム(
    • Place of Presentation
      石和温泉・慶山(山梨)
    • Related Report
      2012 Final Research Report
  • [Presentation] リスザルは 1 種類の IgG しか持たず2012

    • Author(s)
      東岸任弘、中村昇太、朴辰幸、片貝祐子、保富康宏、立花太郎、堀井俊宏
    • Organizer
      感染症若手フォーラム
    • Place of Presentation
      海の見えるホテル(長崎)
    • Related Report
      2012 Final Research Report
  • [Presentation] リスザルは単一のIgGを持ち、サブクラスを持たない2012

    • Author(s)
      東岸任弘、中村昇太、朴辰幸、片貝祐子、保富康宏、立花太郎、堀井俊宏
    • Organizer
      日本実験動物科学・技術 九州2012
    • Place of Presentation
      ビーコンプラザ(大分)
    • Related Report
      2012 Annual Research Report
  • [Presentation] リスザルは1種類のIgGを持ち、サブクラスを持たない2012

    • Author(s)
      東岸任弘、中村昇太、朴辰幸、片貝祐子、保富康宏、立花太郎、堀井俊宏
    • Organizer
      NGS現場の会 第2回研究会
    • Place of Presentation
      ホテル阪急エキスポパーク(大阪)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Squirrel monkey has a single IgG and no IgG subclasses2012

    • Author(s)
      Takahiro Tougan, Shota Nakamura, Chin-Heng Paku, Yuko Katakai, Yasuhiro Yasutomi, Taro Tachibana and Toshihiro Horii
    • Organizer
      5th International CVRDC-RIMD Joint Symposium
    • Place of Presentation
      SEOGWIPO KAL HOTEL(韓国・済州島)
    • Related Report
      2012 Annual Research Report
  • [Presentation] リスザルは単一のIgGを持ち、サブクラスを持たない2012

    • Author(s)
      東岸任弘、中村昇太、朴辰幸、片貝祐子、保富康宏、立花太郎、堀井俊宏
    • Organizer
      日本分子生物学会 第12回 春季シンポジウム
    • Place of Presentation
      石和温泉・慶山(山梨)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新規アジュバント添加による次世代 SE36 マラリアワクチンの開発と実用化:旅行者用ワクチンへのアプローチ /Development and application of next generation SE36 malaria vaccine formulated with a novel adjuvant: approach to travelers' vaccine2011

    • Author(s)
      東岸任弘、青枝大貴、八木正典、有末伸子、片貝祐子、保富康宏、甲斐知恵子、石井健、堀井俊宏
    • Organizer
      第7回霊長類医科学フォーラム
    • Place of Presentation
      研究交流センター 国際会議場(茨城)
    • Year and Date
      2011-11-18
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規アジュバント添加による次世代SE36マラリアワクチンの開発と実用化:旅行者用ワクチンへのアプローチ2011

    • Author(s)
      東岸任弘、青枝大貴、八木正典、有末伸子、片貝祐子、保富康宏、甲斐知恵子、石井健、堀井俊宏
    • Organizer
      第7回霊長類医科学フォーラム
    • Place of Presentation
      研究交流センター国際会議場(茨城)(招待講演)
    • Year and Date
      2011-11-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of next generation SE36 malaria vaccine formulated with a novel adjuvant : approach to travelers' vaccine2011

    • Author(s)
      Takahiro Tougan, Taiki Aoshi, Masanori Yagi, Cevayir Coban, Nobuko Arisue, Yuko Katakai, Yasuhiro Yasutomi, Chieko Kai, Ken J.Ishii, Toshihiro Horii
    • Organizer
      Nagasaki Symposium on Malaria Biology 2011 (II)
    • Place of Presentation
      長崎大学(長崎)(招待講演)
    • Year and Date
      2011-11-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of next generation SE36 malaria vaccine formulated with a novel adjuvant : approach to travelers' vaccine2011

    • Author(s)
      Takahiro Tougan, Taiki Aoshi, Masanori Yagi, Cevayir Coban, Nobuko Arisue, Yuko Katakai, Yasuhiro Yasutomi, Chieko Kai, Ken J.Ishii, Toshihiro Horii
    • Organizer
      第17回日独厘虫病シンポジウム
    • Place of Presentation
      奈良女子大学(奈良)
    • Year and Date
      2011-09-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of next generation SE36 malaria vaccine formulated with a novel adjuvant : approach to travelers' vaccine2011

    • Author(s)
      Takahiro Tougan, Taiki Aoshi, Masanori Yagi, Cevayir Coban, Nobuko Arisue, Yuko Katakai, Yasuhiro Yasutomi, Chieko Kai, Ken J.Ishii, Toshihiro Horii
    • Organizer
      IUMS (International Union of Microbiological Societies) 2011 Congress
    • Place of Presentation
      Sapporo Convention Center, Sapporo Business Innovation Center(北海道)
    • Year and Date
      2011-09-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] Squirrel monkey has a single IgG and no IgG subclasses2011

    • Author(s)
      Takahiro Tougan, Shota Nakamura, Chin-Heng Paku, Yuko Katakai, Yasuhiro Yasutomi, Taro Tachibana and Toshihiro Horii
    • Organizer
      第34回分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Development of next generation SE36 malaria vaccine formulated with a novel adjuvant: approach to travelers' vaccine2011

    • Author(s)
      Takahiro Tougan, Taiki Aoshi, Masanori Yagi, Cevayir Coban, Nobuko Arisue, Yuko Katakai, Yasuhiro Yasutomi, Chieko Kai, Ken J. Ishii and Toshihiro Horii
    • Organizer
      Nagasaki Symposium on Malaria Biology 2011 (II)
    • Place of Presentation
      長崎大学(長崎)
    • Related Report
      2012 Final Research Report
  • [Presentation] Development of next generation SE36 malaria vaccine formulated with a novel adjuvant: approach to travelers' vaccine2011

    • Author(s)
      Takahiro Tougan, Taiki Aoshi, Masanori Yagi, Cevayir Coban, Nobuko Arisue, Yuko Katakai, Yasuhiro Yasutomi, Chieko Kai, Ken J. Ishii and Toshihiro Horii
    • Organizer
      17th Japanese-German Cooperative Symposium on Protozoan Diseases
    • Place of Presentation
      奈良女子大学(奈良)
    • Related Report
      2012 Final Research Report
  • [Presentation] Development of next generation SE36 malaria vaccine formulated with a novel adjuvant: approach to travelers' vaccine.2011

    • Author(s)
      Takahiro Tougan, Taiki Aoshi, Masanori Yagi, Cevayir Coban, Nobuko Arisue, Yuko Katakai, Yasuhiro Yasutomi, Chieko Kai, Ken J. Ishii and Toshihiro Horii
    • Organizer
      IUMS (International Union of Microbiological Societies) 2011 Congress
    • Place of Presentation
      Sapporo Convention Center, Sapporo Business Innovation Center (北海道)
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規アジュバント添加による次世代SE36マラリアワクチンの開発と実用化:旅行者用ワクチンへのアプローチ2010

    • Author(s)
      東岸任弘・石井健・堀井俊宏
    • Organizer
      第14回日本ワクチン学会学術集会
    • Place of Presentation
      九段会館(東京)
    • Year and Date
      2010-12-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規アジュバント添加による次世代SE36マラリアワクチンの開発と実用化:旅行者用ワクチンへのアプローチ2010

    • Author(s)
      東岸任弘・青枝大貴・八木正典・有末伸子・片貝祐子・保富康宏・甲斐知恵子・石井健・堀井俊宏
    • Organizer
      第79回日本寄生虫学会大会
    • Place of Presentation
      旭川市大雪クリスタルホール(北海道)
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規アジュバント添加による次世代 SE36 マラリアワクチンの開発と実用化:旅行者用ワクチンへのアプローチ2010

    • Author(s)
      東岸任弘・石井健・堀井俊宏
    • Organizer
      第14回日本ワクチン学会学術集会
    • Place of Presentation
      九段会館(東京)
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規アジュバント添加による次世代SE36 マラリアワクチンの開発と実用化:旅行者用ワクチンへのアプローチ/Development and application of next generation SE36 malaria vaccine formulated with a novel adjuvant: approach to travelers' vaccine.2010

    • Author(s)
      東岸任弘・青枝大貴・八木正典・有末伸子・片貝祐子・保富康宏・甲斐知恵子・石井健・堀井俊宏
    • Organizer
      第79回日本寄生虫学会大会
    • Place of Presentation
      新規アジュバント添加による次世代SE36 マラリアワクチンの開発と実用化:旅行者用ワクチンへのアプローチ/Development and application of next generation SE36 malaria vaccine formulated with a novel adjuvant: approach to travelers' vaccine.
    • Related Report
      2012 Final Research Report
  • [Book] Vaccine2011

    • Author(s)
      Palacpac NM, Arisue N, Tougan T, Ishii KJ, Horii T
    • Related Report
      2012 Final Research Report
  • [Book] Methods Mol Biol2011

    • Author(s)
      Nojima H, Tougan T
    • Related Report
      2012 Final Research Report
  • [Book] 綜合臨牀2011

    • Author(s)
      東岸任弘、堀井俊宏
    • Related Report
      2012 Final Research Report
  • [Book] Pharma Medica2011

    • Author(s)
      東岸任弘、田邊和裄、堀井俊宏
    • Related Report
      2012 Final Research Report
  • [Book] マラリアワクチン2011

    • Author(s)
      東岸任弘、堀井俊宏
    • Total Pages
      5
    • Publisher
      永井書店
    • Related Report
      2011 Annual Research Report
  • [Book] マラリアワクチンの開発2011

    • Author(s)
      東岸任弘、堀井俊宏
    • Total Pages
      5
    • Publisher
      メディカルレビュー社
    • Related Report
      2011 Annual Research Report
  • [Book] Methods in molecular biology・Preparation of a High-Quality cDNA Library from a Single-Cell Quantity of mRNA Using Chum-RNA.2011

    • Author(s)
      Nojima H, Tougan T.
    • Publisher
      Springer
    • Related Report
      2010 Annual Research Report
  • [Book] 臨床粘膜免疫学2010

    • Author(s)
      東岸任弘、堀井俊宏
    • Publisher
      株式会社シナジー
    • Related Report
      2012 Final Research Report
  • [Book] 臨床検査2010

    • Author(s)
      東岸任弘、堀井俊宏
    • Related Report
      2012 Final Research Report
  • [Book] 東次世代ワクチンの産業応用技術2010

    • Author(s)
      東岸任弘、石井健、堀井俊宏
    • Related Report
      2012 Final Research Report
  • [Book] 新薬展望2010

    • Author(s)
      東岸任弘、堀井俊宏
    • Related Report
      2012 Final Research Report
  • [Book] DDS(DDS 学会誌)2010

    • Author(s)
      東岸任弘、石井 健、堀井俊宏
    • Related Report
      2012 Final Research Report
  • [Book] 次世代ワクチンの産業応用技術・マラリアワクチンの実現に向けて2010

    • Author(s)
      東岸任弘、石井健、堀井俊宏
    • Publisher
      (株)シーエムシー出版
    • Related Report
      2010 Annual Research Report
  • [Book] 臨床検査 増刊号・マラリア2010

    • Author(s)
      東岸任弘、堀井俊宏
    • Publisher
      (株)医学書院
    • Related Report
      2010 Annual Research Report
  • [Book] 臨床粘膜免疫学・寄生虫による粘膜感染2010

    • Author(s)
      東岸任弘、堀井俊宏
    • Publisher
      株式会社シナジー
    • Related Report
      2010 Annual Research Report
  • [Remarks] 大阪大学・微生物病研究所・分子原虫学分野ホームページ

    • URL

      http://www.biken.osaka-u.ac.jp/lab/protozool/index.html

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.biken.osaka-u.ac.jp/kenkyu/kansen/Protozool/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.biken.osaka-u.ac.jp/kenkyu/kansen/Protozool/index.html

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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