| Budget Amount *help |
¥6,045,000 (Direct Cost: ¥4,650,000、Indirect Cost: ¥1,395,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,015,000 (Direct Cost: ¥1,550,000、Indirect Cost: ¥465,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
In mammals, a fundamental function differs between maternaland paternal genomes. We found that exogenous DNA was controlled differently in its methylation status after injection into the female or male pronucleus. When H19 imprinting control region was used for exogenous DNA, its methylation level was higher in male pronucleus injection than that by female pronuleus injection. This result suggests that maternal and paternal specific epigeneteic marks in embryos may contribute in the establishment and maintenance of parental origin specific methylation of imprinting genesafter fertilization.
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