Development and evaluation of Carbon-nanotube-bundle electrodes for neural interface

• Project/Area Number: 22700472
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Osaka University (2011-2012); Kumamoto University (2010)
• Principal Investigator: HAYASHIDA Yuki 大阪大学, 大学院・工学研究科, 准教授 (10381005)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 生体材料 / 生物・生体工学 / ナノチューブ / 神経工学 / 神経用途電極 / 神経補綴 / 神経生理学 / 神経科学 / 生理学

Research Abstract

Flexible, needle-shaped electrodes with the tip diameters of nano/micro-meter sizes were fabricated by assembling the bundles of carbon nanotubes (CNT), and their capabilities as neural electrodes were evaluated in physiological experiments with preparations of biological neurons and brain tissues. The experimental results demonstrated that the CNT-bundle electrodes we developed are useful as neuron-penetrating intracellular and brain-penetrating extracellular, stimulating/recording electrodes. These electrodes are unprecedented in the world, and may offer a new possibility for neural interface.

Research Products

• [Journal Article] Interfacing neurons through the patch membrane pierced with single-walled carbon nanotubes (2013)
  • Author(s): Y. Hayashida, T. Kinoshita, T. Motomura
  • Journal Title: Conference Proceedings of IEEE Engineering in Medicine and Biology Society
  • Peer Reviewed
• [Presentation] brain-penetrating extracellular electrode made of carbon nanotube bundles (2012)
  • Author(s): T. Yamakawa, Y. Hayashi da, T. Ko zuno
  • Organizer: Society for Neuroscience's 42nd annual meeting
  • Place of Presentation: Ernest N. Morial Convention Center, New Orleans, LA, USA
  • Year and Date: 2012-10-14
• [Presentation] Flexible, needle-shaped neuroelectrodes made of carbon nanotube bundles. (2012)
  • Author(s): Y. Hayashida, T. Yamakawa, S. Harabe, T. Kozuno, N. Murayama
  • Organizer: The 35th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 名古屋国際会議場, 愛知県名古屋市
  • Year and Date: 2012-09-18
• [Presentation] On t he dynami cs o f si gnal propagation in the mouse primary visual cortical circuit. (2012)
  • Author(s): T. Kozuno, Y. Hayashida, Y. Shimada, T. Yagi
  • Organizer: Japan Neuroscience Society
  • Place of Presentation: 名古屋国際会議場, 愛知県名古屋市
  • Year and Date: 2012-09-18
• [Presentation] 細胞外神経刺激のためのカーボンナノチューブバンドル電極 (2012)
  • Author(s): 林田祐樹,山川隆洋,小津野将
  • Organizer: 平成24年電気学会 電子・情報システム部門大会
  • Place of Presentation: 弘前大学文京町キャンパス, 青森県弘前市
  • Year and Date: 2012-09-06
• [Presentation] マウス視覚野における時空間信号伝播のイメージングおよび細胞外電位同時計測 (2012)
  • Author(s): 小津野将,林田祐樹,島田義規,八木哲也
  • Organizer: 平成24年電気学会 電子・情報システム部門大会
  • Place of Presentation: 弘前大学文京町キャンパス, 青森県弘前市
  • Year and Date: 2012-09-05
• [Presentation] ニードル型カーボンナノチューブバンドル電極の電気的特性 (2012)
  • Author(s): 山川隆洋,林田祐樹,原部翔,小津野将,村山伸樹,奥野弘嗣,八木哲也
  • Organizer: 電子情報通信学会MEとバイオサイバネティクス研究会
  • Place of Presentation: 玉川大学, 東京都町田市.
  • Year and Date: 2012-03-16
• [Presentation] ニードル型カーボンナノチューブバンドル電極の電気的特性 (2012)
  • Author(s): 山川隆洋, 林田祐樹, 原部翔, 小津野将, 村山伸樹, 他2名
  • Organizer: MEとバイオサイバネティクス研究会(信学技法,Vol.1111,No.482,pp.171-174,2012)
  • Place of Presentation: 東京都町田市,玉川大学
  • Year and Date: 2012-03-16
• [Presentation] A brain-penetrating extracellular electrode made of carbon nanotube bundles. (2012)
  • Author(s): T. Yamakawa, Y. Hayashida（代表者）, T. Kozuno.
  • Organizer: Society for Neuroscience's 42nd annual meeting, Nueorscience 2012
  • Place of Presentation: Ernest N. Morial Convention Center, New Orleans, LA, U.S.A.
• [Presentation] Flexible, needle-shaped neuro-electrodes made of carbon nanotube bundles. (2012)
  • Author(s): Y. Hayashida（代表者）, T. Yamakawa, S. Harabe, T. Kozuno, N. Murayama
  • Organizer: The 35th Annual Meeting of the Japan Neuroscience Society, Neuroscience 2012
  • Place of Presentation: 愛知県名古屋市，名古屋国際会議場
• [Presentation] On the dynamics of signal propagation in the mouse primary visual cortical circuit. (2012)
  • Author(s): T. Kozuno, Y. Hayashida（代表者）, Y. Shimada, T. Yagi
  • Organizer: The 35th Annual Meeting of the Japan Neuroscience Society, Neuroscience 2012
  • Place of Presentation: 愛知県名古屋市，名古屋国際会議場
• [Presentation] 細胞外神経刺激のためのカーボンナノチューブバンドル電極． (2012)
  • Author(s): 林田祐樹(代表者)，山川隆洋，小津野将
  • Organizer: 平成24年電気学会 電子・情報・システム部門大会
  • Place of Presentation: 青森県弘前市，弘前大学文京町キャンパス
• [Presentation] マウス視覚野における時空間信号伝播のイメージングおよび細胞外電位同時計測． (2012)
  • Author(s): 小津野将，林田祐樹（代表者），島田義規，八木哲也
  • Organizer: 平成24年電気学会 電子・情報・システム部門大会
  • Place of Presentation: 青森県弘前市，弘前大学文京町キャンパス
• [Presentation] Toward Neuronal Interface with Carbon Nanotubes. (2011)
  • Author(s): Y. Hayashida, S. Harabe, T. Kinoshita, T. Motomura, N. Murayama
  • Organizer: 計測自動制御学会 第26回生体・生理工学シンポジウム
  • Place of Presentation: 立命館大学びわこ・くさつキャンパス, 滋賀県草津市
  • Year and Date: 2011-09-20
• [Presentation] Toward Neuronal Interface with Carbon Nanotubes(カーボンナノチューブによる神経細胞インターフェイスの可能性) (2011)
  • Author(s): Y Hayashida, S Harabe, T.Kinoshita, T.Motomura, 他2名
  • Organizer: 第26回生体生理工学シンポジウム(Proc.26th Symposium on Biological and Physiological Engineerings, pp.303-305, 2011)
  • Place of Presentation: 滋賀県草津市,立命館大学びわこ・くさつキャンパス
  • Year and Date: 2011-09-20
• [Presentation] Intracellular electrical stimulation of neurons with penetrating carbon nanotube bundle electrodes (2010)
  • Author(s): Y. Hayashida, S. Harabe, K. Kohira, T. Motomura, N. Murayama
  • Organizer: Society for Neuroscience's 40nd annual meeting
  • Place of Presentation: San Diego Convention Center, San Diego, CA, USA
  • Year and Date: 2010-11-17
• [Presentation] Intracellular electrical stimulation of neurons with penetrating carbon nanotube bundle electrodes (Program#817.10) (2010)
  • Author(s): Yuki Hayashida
  • Organizer: Neuroscience 2010, Society for Neuroscience's 40th Annual Meeting
  • Place of Presentation: San Diego Convention Center (California, U.S.A.)
  • Year and Date: 2010-11-17