| Project/Area Number |
22700477
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 人工臓器工学・再生医工学 / 腹膜線維症 / HGF / BMP-7 / 積層型細胞シート / 遺伝子治療 / 肝細胞増殖因子(HGF) / 線維症 / 細胞療法 / 再生医療 / 細胞シート / 組織工学 / 腹膜傷害マウス / 遺伝子導入細胞 |
|---|
| Research Abstract |
Cell sheet engineering techniques as a cell therapy, hepatocyte growth factor(HGF) and bone morphogenetic protein 7(BMP-7) as a strong repairing factor for damaged tissue were focused. We developed the HGF and BMP-7 genetic stacking mesothelial cell sheets using the HGF transgenic cell sheets and the BMP-7 transgenic cell sheets.
The developed genetic stacking cell sheets can be applied for repairing damaged by fibrosis.
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