| Project/Area Number |
22700488
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | CEST法 / 高分子ミセル / MRI造影剤 / ターゲティング / 固形がん / MRI / ポリイオンコンプレックス / 高感度 |
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| Research Abstract |
We developed novel MRI contrast agent, chemical exchange saturation transfer(CEST) contrast agent, to obtain the image that show high signal to noise ratio by means of magnetization transfer method. A new chelate group for Eu(III) was prepared, and we optimized the condition of the chelate conjugation to PEG-P(Lys) block copolymer. However, NMR experiments indicated that too high extent of chelate conjugation led to lower the mobility of the block copolymer in water. In contrast, appropriate water exchange rate was obtained when we control the composition of block copolymer, and the block copolymer showed CEST effect, effectively.
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