Development and medical applications of novel tissue-adhesive biomaterials that can release proteins in a sustained manner
| Project/Area Number |
22700490
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 組織接着材 / 高分子ミセル / 自己組織化体 / バイオマテリアル / ハイドロゲル / ブロック共重合体 |
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| Research Abstract |
A novel tissue-adhesive hydrogel was prepared by using a "trilayered" polymeric micelle consisting of an aldehyde-terminated poly(ethylene glycol)-poly(D, L-lactide)(PEG-PLA) block polymer. A Schiff base is chemically formed between the amino groups in a polyallylamine and the aldehyde groups on the surface of polymeric micelles. The hydrogel was rapidly formed when the polymeric micelle solution and polyamine solution were mixed in vitro. The hydrogel was rapidly formed in vivo, and it adhered to a tissue surface.
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Report
(3 results)
Research Products
(12 results)
