| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
A novel tissue-adhesive hydrogel was prepared by using a "trilayered" polymeric micelle consisting of an aldehyde-terminated poly(ethylene glycol)-poly(D, L-lactide)(PEG-PLA) block polymer. A Schiff base is chemically formed between the amino groups in a polyallylamine and the aldehyde groups on the surface of polymeric micelles. The hydrogel was rapidly formed when the polymeric micelle solution and polyamine solution were mixed in vitro. The hydrogel was rapidly formed in vivo, and it adhered to a tissue surface.
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