Preparation and characterization of polyion complex nanoparticles using hydrophobic interaction
| Project/Area Number |
22700493
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Osaka University |
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Principal Investigator |
AKAGI Takami 大阪大学, 大学院・工学研究科, 特任准教授 (00527236)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ドラックデリバリーシステム(DDS) / ナノ粒子 / ポリイオンコンプレックス / 疎水性相互作用 / ドラッグデリバリーシステム / ポリ(γ-グルタミン酸) / ワクチン |
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| Research Abstract |
Polyion complex(PIC) nanoparticles composed of anionic hydrophobically modified and cationic poly(amino acid) were prepared using electrostatic and hydrophobic interactions between the two polymers. The prepared PIC nanoparticles showed high stability for a prolonged period of time under physiological conditions. The improved stability of the PIC nanoparticles was attributed to the formation of hydrophobic domains in the core of the nanoparticles. Moreover, the function of the PIC nanoparticles as a protein carrier was demonstrated.
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Report
(3 results)
Research Products
(32 results)
