| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
In the present study, we have fabricated “chelate-setting apatite cements (IP6-HAp cements)” using HAp particles surface-modified with inositol hexaphosphate (IP6) and evaluated their anti-tumor effect. Osteosarcoma cultured on IP6-HAp cements (over 3000 ppm IP6) resulted in inhibition of cell growth, although normal cells grew well on those cements. These results led us to consider that locally high concentration of IP6 which was released from cement acts on the cells directly as anti-tumor agent and induces the apoptosis. Consequently, IP6-HAp cement might gain the anti-tumor effect and act as a carrier for local drug delivery system.
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