| Project/Area Number |
22700511
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical systems
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| Research Institution | Kumamoto University |
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Principal Investigator |
ABE Keisuke 熊本大学, 大学院・自然科学研究科, COEリサーチ・アソシエイト (10535652)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 臓器保存 / 治療システム / 高周波高電界パルスがん治療 / がん治療 / ナノ秒パルス高電界 / バースト正弦波高電界 / Apoptosis / セラミド / 小胞体ストレス / ナノ秒高電 / アポトーシス / CERAMIDE / イオン流入 / c-Jun |
|---|
| Research Abstract |
In this study, we found that nanosecond pulsed electric field(nsPEF) caused apoptosis like death to cancer cells. nsPEF(120ns width) promoted Ca^<2+> influx to cytoplasm, and Ceramide was expressed on cell membrane. These factors activated endoplasmic reticulum stress signal and caused apoptosis. Moreover, Intense Burst Sinusoidal Electric Field(3-10MHz) cannot damaged cell membrane. In case of a certain low energy, it activated cell proliferation.
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