Investigation on biosensor using interaction between ultrasound and microbubble

• Project/Area Number: 22700517
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Medical systems
• Research Institution: Doshisha University
• Principal Investigator: YOSHIDA Kenji 同志社大学, 高等研究教育機構, 助手 (10572985)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 超音波 / マイクロバブル / 共振 / 抗原抗体反応 / 共振特性 / 生体分子

Research Abstract

The goal of this research is to fabricate biosensing microbubbles by using interaction with ultrasound and to construct the measurement system for evaluating the performance as the biosensor. It was succeeded in fabricating the precursor of biosensing microbubbles on which antibodies can be stably bound via avidin-biotin binding. The system by using Laser Doppler vibrometer was proposed to measure the resonance characteristic of microbubbles which significantly relates to the sensitivity and accuracy in the biosensor application. The constructed system enabled to measure the characteristics for microbubble with radius more than 50μm.

Research Products

• [Journal Article] Measurement of the resonant characteristics of a single bubble vibration by using a laser Doppler vibrometer (2011)
  • Author(s): T. Yoshikawa, H. Kotera, K. Yoshida, D. Koyama, K. Nakamura and Y. Watanabe
  • Journal Title: Jpn. J. Appl. Phys. Volume: Vol.50 Issue: 7S Pages: 1-3
  • DOI: 10.1143/jjap.50.07he04
  • NAID: 210000070922
  • Peer Reviewed
• [Presentation] 超音波照射下において固体表面の濡れ性が付着マイクロバブルの振動に与える影響 (2011)
  • Author(s): 吉田憲司, 森岡俊一, 上田優都, 小山大介, 中村健太郎, 渡辺好章
  • Organizer: 超音波研究会
  • Place of Presentation: 静岡
  • Year and Date: 2011-11-24
• [Presentation] 超音波照射下において固体表面の濡れ性が付着マイクロバブルの振動に与える影響 (2011)
  • Author(s): 吉田憲司、森岡俊一、上田優都、小山大介、中村健太郎、渡辺好章
  • Organizer: 超音波研究会
  • Place of Presentation: 東海大学清水キャンパス(静岡市)
  • Year and Date: 2011-11-24
• [Presentation] Experimental measurement of microbubble oscillation by using laser Doppler vibrometer (2011)
  • Author(s): Kenji Yoshida, Taisuke Yoshikawa, Daisuke Koyama, Kentaro Nakamura and Yoshiaki Watanabe
  • Organizer: International congress on ultrasonics
  • Place of Presentation: Gdansk, Poland
  • Year and Date: 2011-09-08
• [Presentation] Experimental measurement of microbubble oscillation by using laser Doppler vibrometer (2011)
  • Author(s): Kenji Yoshida, Taisuke Yoshikawa, Daisuke Koyama, Kentaro Nakamura, Yoshiaki Watanabe
  • Organizer: International congress on ultrasonics 2011
  • Place of Presentation: University of Gdansk (Gdansk、Poland)
  • Year and Date: 2011-09-08
• [Presentation] レーザドップラ振動計を用いた生分解性カプセルの振動計測 (2010)
  • Author(s): 吉田憲司, 小寺宏典, 田畑拓, 小山大介, 中村健太郎, 渡辺好章
  • Organizer: 日本音響学会2010年秋季研究発表会
  • Place of Presentation: 吹田
  • Year and Date: 2010-09-24
• [Presentation] レーザドップラ振動計を用いた生分解性マイクロカプセルの振動計測 (2010)
  • Author(s): 吉田憲司
  • Organizer: 日本音響学会2010年秋季研究発表会
  • Place of Presentation: 関西大学千里山キャンパス(大阪 吹田市)
  • Year and Date: 2010-09-16