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New diagnostic technique for malignant melanoma by blood flow velocity imaging

Research Project

Project/Area Number 22700521
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Medical systems
Research InstitutionNational Institute of Technology, Toyama College

Principal Investigator

ISHIDA Hiroki  富山高等専門学校, 電子情報工学科, 准教授 (50413761)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords画像診断システム / 腫瘍診断 / 新生血管 / 血流速
Research Abstract

We have developed a micro multipoint laser Doppler velocimeter(μ-MLDV) for in-vivo visualization of melanoma tumor based on flow velocities. Malignant transformation results in a sudden rapid increase in growth along with the formation of new blood vessels to supply oxygen, nutrients, and metabolites to cancer cells. The blood flow velocity in a lesion more than doubled 9 days after transplantation. After 12 days, we observed the formation of new blood vessels in the tumor. Theμ-MLDV is potentially a useful diagnostic technique for distinguishing benign and malignant tumors.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (5 results)

All 2012 2011 2010

All Journal Article (5 results) (of which Peer Reviewed: 5 results)

  • [Journal Article] Measurement of blood flow velocity in a model of stenosis in vitro and in mesenteric vessels in vivo using non-invasive micro multi laser Doppler velocimetry2012

    • Author(s)
      S. Akiguchi, H. Ishida, T. Andoh, T. Hachiga, T. Shimizu, Y. Kuraishi, H. Shirakawa, and K. Ueyama
    • Journal Title

      Measurement Science and Technology

      Volume: vol.23 Issue: 4 Pages: 45702-45702

    • DOI

      10.1088/0957-0233/23/4/045702

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Noninvasive In-vivo Measurements of Microvessels by Reflection-type Micro Multipoint Laser Doppler Velocimeter2012

    • Author(s)
      H. Ishida, T. Andoh, S. Akiguchi, T. Hachiga, M. Ishizuka, T. Shimizu, H. Shirakawa, and Y. Kuraishi
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: vol.51 Issue: 3R Pages: 32701-32701

    • DOI

      10.1143/jjap.51.032701

    • NAID

      40019199543

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reflection-type micro multipoint LDV for measuring velocity distributions in blood vessels2011

    • Author(s)
      H. Ishida, D. Kobayashi, H. Shirakawa, T. Andoh, S. Akiguchi, T. Wakisaka, M. Ishizuka, and T. Hachiga
    • Journal Title

      Review of Scientific Instruments

      Volume: vol.82 Issue: 7

    • DOI

      10.1063/1.3609864

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blood flow velocity imaging of malignant melanoma by micro multi-point laser Doppler velocimetry2010

    • Author(s)
      H. Ishida, T. Andoh, S. Akiguchi, H. Shirakawa, D. Kobayashi, Y. Kuraishi, and T. Hachiga
    • Journal Title

      Applied Physics Letters

      Volume: vol.97 Issue: 10

    • DOI

      10.1063/1.3486678

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blood flow velocity imaging of malignant melanoma by micro multi-point laser Doppler velocimetry2010

    • Author(s)
      H.Ishida, T.Andoh, S.Akiguchi, H.Shirakawa, D.Kobayashi, Y.Kuraishi, T.Hachiga
    • Journal Title

      Applied Physics Letters

      Volume: 97

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed

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Published: 2010-08-23   Modified: 2016-04-21  

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