Study of activation mechanism of satellite cell : Basis for elucidate an efficient training method

• Project/Area Number: 22700530
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Kanazawa University
• Principal Investigator: TANAKA Shoji 金沢大学, 保健学系, 助教 (70422657)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: リハビリテーション / 骨格筋 / 肥大 / 筋肥大 / 筋分化制御因子

Research Abstract

We investigated the role of hepatocyte growth factor in the satellite cell mechanism of activation related to the skeletal muscle hypertrophy in vivo in rat. The results show that whereas the levels of the hepatocyte growth factor receptor and that of the muscle differentiation factor increased in response to muscle load, the levels of hepatocyte growth factor remained unchanged. These results suggest that the qualitative changes rather than quantitative changes of hepatocyte growth factor may be more important for the satellite cell activation.

Research Products

• [Presentation] 筋活動がAChR凝集機構に与える影響 (2010)
  • Author(s): 田中正二
  • Organizer: 第45会日本理学療法学術大会
  • Place of Presentation: 長良川国際会議場(岐阜県)
  • Year and Date: 2010-05-27
• [Presentation] 筋活動がAChR凝集機構に与える影響 (2010)
  • Author(s): 田中正二
  • Organizer: 第45回日本理学療法学術大会
  • Place of Presentation: 長良川国際会議場(岐阜県)
  • Year and Date: 2010-05-27
• [Remarks]
  • URL: http://phys_ther.w3.kanazawa-u.ac.jp/staff_10/staff_10.html