Training factor associated with the change ofneuronal activities inthe primary motor cortex

• Project/Area Number: 22700590
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Physical education
• Research Institution: Kochi University of Technology (2011-2012); The University of Tokyo (2010)
• Principal Investigator: KADOTA Hiroshi 高知工科大学, 総合研究所, 講師 (00415366)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 運動学習 / 一次運動野 / 経頭蓋磁気刺激

Research Abstract

Adaptation to a novel dynamical environment accompanies changes of neuronal activities in the primary motor cortex. Here, we investigated the changes resulting from the motor adaptation in human corticospinal excitability thatreflects more macroscopic activity level of the primary motor cortex. We found that the coticospinal excitability exhibited directional tuning property and the preferred direction. The tuning pattern after the adaptation shifted depending on the direction of force field. The corticospinal excitability was systematically modulated depending on the adapted environment and the performed behavior contexts.

Research Products

• [Journal Article] Neurophysiological and dynamical control principles underlying variable and stereotyped movement patterns during skill acquisition. (2011)
  • Author(s): K. Kudo, M. Miyazaki, H. Sekiguchi, H. Kadota, S. Fujii, A. Miura, M. Yoshie and H. Nakata
  • Journal Title: Journal of Advanced Computational Intelligence and Intelligent Informatics Volume: 15 Pages: 942-953
  • Peer Reviewed
• [Journal Article] フォーカル・ジストニアの基礎と臨床. (2011)
  • Author(s): 中島八十一,門田宏
  • Journal Title: 整形・災害外科特集: Musician's Hand Volume: 54 Pages: 357-364
• [Journal Article] TMS-induced artifacts on EEG can be reduced by rearrangement of the electrode's lead wire before recording (2011)
  • Author(s): Sekiguchi, H., Takeuchi, S., Kadota, H.,Kohno, Y., & Nakajima, Y.
  • Journal Title: Clinical Neurophysiology Volume: 122(5) Issue: 5 Pages: 984-990
  • DOI: 10.1016/j.clinph.2010.09.004
  • Peer Reviewed
• [Journal Article] Neurophysiological and dynamical control principles underlying variable and stereotyped movement patterns during skill acquisition (2011)
  • Author(s): Kudo, K.Miyazaki, M.Sekiguchi, H.Kadota, H.Fujii, S.Miura, A.Yoshie, M., Nakata, H.
  • Journal Title: Journal of Advanced Computational Intelligence and Intelligent Informatics Volume: Vol.15 Pages: 942-953
  • Peer Reviewed
• [Journal Article] フォーカル・ジストニアの基礎と臨床 (2011)
  • Author(s): 中島八十一、門田宏
  • Journal Title: 整形・災害外科 Volume: 54巻 Pages: 357-364
• [Journal Article] TMS-induced artifacts on EEG can be reduced by rearrangement of the electrode's lead wire before recording (2011)
  • Author(s): Sekiguchi H, Takeuchi S, Kadota H, Kohno Y, Nakajima Y
  • Journal Title: Clinical Neurophysiology Volume: 122 Pages: 984-90
  • Peer Reviewed
• [Journal Article] The role of the dorsolateral prefrontal cortex in the inhibition of stereotyped responses (2010)
  • Author(s): Kadota H, Sekiguchi H, Takeuchi S, Miyazaki M, Kohno Y, Nakajima Y
  • Journal Title: Experimental Brain Research Volume: 203 Issue: 3 Pages: 593-600
  • DOI: 10.1007/s00221-010-2269-4
  • Peer Reviewed
• [Journal Article] An fMRI study of musicians with focal dystonia during tapping tasks (2010)
  • Author(s): Kadota H, Nakajima Y, Miyazaki M, Sekiguchi H, Kohno H, Amako M, Arino H, Nemoto K, Sakai N
  • Journal Title: Journal of Neurology Volume: 257 Issue: 7 Pages: 1092-1098
  • DOI: 10.1007/s00415-010-5468-9
  • Peer Reviewed
• [Journal Article] The role of the dorsolateral prefrontal cortex in the inhibition of stereotyped response (2010)
  • Author(s): Kadota H, Sekiguchi H, Takeuchi S, Miyazaki M, Kohno Y, Nakajima Y
  • Journal Title: Experimental Brain Research Volume: 203 Pages: 593-600
  • Peer Reviewed
• [Journal Article] An fMRI study of musicians with focal dystonia during tapping tasks (2010)
  • Author(s): Kadota H, Nakajima Y, Miyazaki M, Sekiguchi H, Kohno Y, Amako M, Arino H, Nemoto K, Sakai N
  • Journal Title: Journal of Neurology Volume: 257 Pages: 1092-8
  • Peer Reviewed
• [Presentation] Distinction between neural correlates for temporal order and simultaneity judgments (2012)
  • Author(s): M. Miyazaki, H. Kadota, S. Matsuzaki K., S. Takeuchi, H. Sekiguchi and T. Kochiyama
  • Organizer: Society for Neuroscience
  • Place of Presentation: New Orleans, America
  • Year and Date: 2012-10-17
• [Presentation] Dissociating neural correlates for simultaneity and temporal-order judgments (2012)
  • Author(s): M. Miyazaki, H. Kadota, S. Matsuzaki K., S. Takeuchi, H. Sekiguchi and T. Kochiyama
  • Organizer: Neuro2012
  • Place of Presentation: Nagoya
  • Year and Date: 2012-09-20
• [Presentation] Modulation of TMS-induced EEG dynamics during motor execution and inhibition (2012)
  • Author(s): K. Yamanaka, H. Kadotaand N. Daichi
  • Organizer: Conference on systems neuroscience and rehabilitation
  • Place of Presentation: College of National Rehabilitation Center for Persons with Disabilities
• [Presentation] Modulation of TMS-induced EEG dynamics during motor execution and inhibition (2012)
  • Author(s): Yamanaka, K.Kadota. H., Daichi, N.
  • Organizer: Conference on systems neuroscience and rehabilitation
  • Place of Presentation: College of National Rehabilitation Center for Persons with Disabilities (Japan)
• [Presentation] Cortical responses induced by transcranial magnetic stimulation to motor cortex during motor execution and inhibition (2011)
  • Author(s): K. Yamanaka, H. Kadotaand N. Daichi
  • Organizer: Society for Neuroscience
  • Place of Presentation: Washington DC, America
  • Year and Date: 2011-11-15
• [Presentation] Cortical responses induced by transcranial magnetic stimulation to motor cortex during motor execution and inhibition (2011)
  • Author(s): Yamanaka, K.Kadota, H., Daichi, N.
  • Organizer: Society for Neuroscience
  • Place of Presentation: Washington DC (America)
  • Year and Date: 2011-11-15
• [Presentation] Learning-related changes in corticospinal excitability of wrist muscles prior to movement execution (2011)
  • Author(s): H. Kadota, M. Hirashima and N. Daichi
  • Organizer: Neuro2011
  • Place of Presentation: Yokohama
  • Year and Date: 2011-09-16
• [Presentation] Learning-related changes in corticospinal excitability of wrist muscles prior to movement execution (2011)
  • Author(s): Kadota, H.Hirashima, M., Daichi, N.
  • Organizer: Neuro2011
  • Place of Presentation: Pacific Yokohama (Japan)
  • Year and Date: 2011-09-16
• [Presentation] 野崎大地力場学習に伴う皮質脊髄路の興奮性の変化 (2011)
  • Author(s): 門田宏,平島雅也
  • Organizer: 第5回Motor Control 研究会
  • Place of Presentation: 生理学研究所
  • Year and Date: 2011-06-18
• [Presentation] 力場学習に伴う皮質脊髄路の興奮性の変化 (2011)
  • Author(s): 門田宏、平島雅也、野崎大地
  • Organizer: 第5回Motor Control研究会
  • Place of Presentation: 生理学研究所(日本)
  • Year and Date: 2011-06-18
• [Presentation] Adaptation to a novel dynamical environment modifies the corticospinal excitability (2011)
  • Author(s): H. Kadota, M. Hirashima and N. Daichi
  • Organizer: Conference on systems neuroscience and rehabilitation
  • Place of Presentation: College of National Rehabilitation Center for Persons with Disabilities
• [Presentation] Adaptation to a novel dynamical environment modifies the corticospinal excitability (2011)
  • Author(s): Kadota H, Hirashima M, Daichi N
  • Organizer: Conference on Systems Neuroscience and Rehabilitation
  • Place of Presentation: College of National Rehabilitation Center for Persons with Disabilities, Tokorozawa (Japan)
• [Presentation] Motor learning of uni-and bi-manual grip force modulation (2010)
  • Author(s): H. Sekiguchi, S. Takeuchi, H. Kadota, K. Nakazawa, M. Miyazaki, S. Uchida and D. Nozaki
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego, America
  • Year and Date: 2010-11-15
• [Presentation] Adaptation of wrist movements to a novel dynamical environment modifies the directional tuning of corticospinal excitability (2010)
  • Author(s): H. Kadota, M. Hirashima and N. Daichi
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego, America
  • Year and Date: 2010-11-15
• [Presentation] Adaptation of wrist movements to a novel dynamical environment modifies the directional tuning of corticospinal excitability (2010)
  • Author(s): Kadota H, Hirashima M, Daichi N
  • Organizer: Society for Neuroscience
  • Place of Presentation: San Diego (America)
  • Year and Date: 2010-11-15
• [Presentation] TMS-induced artifacts on EEG can be reduced by rearrangement of the electrode's lead wire before recording (2010)
  • Author(s): H. Sekiguchi, S. Takeuchi, H. Kadota, Y. Kohno and Y. Nakajima
  • Organizer: 29th International Congress of Clinical Neurophysiology
  • Place of Presentation: Kobe
  • Year and Date: 2010-11-01
• [Presentation] The effectof TMS on the FB-ERN in time estimation task (2010)
  • Author(s): S. Takeuchi, Y. Mochizuki, H. Kadota, H. Sekiguchi, Y. Kohno and Y. Nakajima
  • Organizer: 29th International Congress of Clinical Neurophysiology
  • Place of Presentation: Kobe
  • Year and Date: 2010-11-01
• [Presentation] TMS-induced artifacts on EEG can be reduced by rearrangement of the electrode's lead wire before recording (2010)
  • Author(s): Sekiguchi H, Takeuchi S, Kadota H, Kohno Y, Nakajima Y
  • Organizer: 29th International Congress of Clinical Neurophysiology
  • Place of Presentation: Kobe International Conference Center, Kobe (Japan)
  • Year and Date: 2010-11-01
• [Presentation] The effects of TMS on the fb-ERN in time estimation task (2010)
  • Author(s): Takeuchi S, Mochizuki Y, Kadota H, Sekiguchi H, Kohno Y, Nakajima Y
  • Organizer: 29th International Congress of Clinical Neurophysiology
  • Place of Presentation: Kobe International Conference Center, Kobe (Japan)
  • Year and Date: 2010-11-01
• [Presentation] Time course of excitability in corticospinal tract after mirror therapy (2010)
  • Author(s): Y. Kohno, H. Sekiguchi, H. Kadota, S. Takeuchi, T. Ueno, H. Nagata and Y. Nakajima
  • Organizer: 29th International Congress of Clinical Neurophysiology
  • Place of Presentation: Kobe
  • Year and Date: 2010-10-31
• [Presentation] Time course of excitability in corticospinal tract after mirror theraphy (2010)
  • Author(s): Kohno Y, Sekiguchi H, Kadota H, Takeuchi S, Ueno T, Nagata H, Nakajima Y
  • Organizer: 29th International Congress of Clinical Neurophysiology
  • Place of Presentation: Kobe International Conference Center, Kobe (Japan)
  • Year and Date: 2010-10-31
• [Presentation] Distinction between neural correlates for temporal order and simultaneity judgments.
  • Author(s): H. Kadota, K. S. Matsuzaki, S. Takeuchi, H. Sekiguchi, T. Kochiyama
  • Organizer: Society for Neuroscience
  • Place of Presentation: New Orleans (America)
• [Presentation] Dissociating neural correlates for simultaneity and temporal-order judgments.
  • Author(s): M. Miyazaki, H. Kadota, K. S. Matsuzaki, S. Takeuchi, H. Sekiguchi, T. Kochiyama
  • Organizer: Neuro 2012
  • Place of Presentation: Nagoya (Japan)