| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
The present study investigated the effect of voluntary exercise during early postnatal period on the abnormal behaviors and developmental disruption of prefrontal cortex induced by early weaning(EW), which is widely used as early life stress. EW caused hyper locomotor activity in the novelty in juvenile and adult animals, whereas this adverse effect of EW was not observed in adult animals which have been exercised voluntary began simultaneously with EW until normal weaning period. In addition, voluntary exercise after EW until normal weaning period prevented disruption of monoaminergic axon development and morphological changes of the pyramidal cell in the prefrontal cortex induced by EW. The present study clearly demonstrated the beneficial effects of voluntary exercise during early postnatal period.
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