The effects of exercise-inducible factors on lipid metabolism in adipocytes
| Project/Area Number |
22700652
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Sports science
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 脂質代謝 / 脂肪分解 / 脂肪滴 / メタボリックシンドローム / 肥満 / 運動 / ミトコ ンドリア / 脂肪燃焼 / 糖尿病 / 糖代謝 / ミトコンドリア / 脂質 / 乳酸 |
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| Research Abstract |
The study investigated the cellular origin and physiological significance of micro lipid droplets (mLDs) that emerge in the cytoplasm during active lipolysis, as well as the roles of key liplolytic proteins on mLDs in differentiated 3T3-L1 adipocytes. The results suggest that, besides the surface of pre-existing central LDs, LD-associated proteins are actively involved in lipolysis on mLDs that are formed by fatty acids re-esterification. Furthermore, the lipolytic activity was increased by exercise-inducible factors such as H2O2, lactate-inducible signals, increased cellular calcium levels, AMP kinase, and nitric oxide inaccordance with elevated levels of LD-associated proteins and mitochondrial biogenic signaling.
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Report
(4 results)
Research Products
(55 results)
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[Journal Article] Active involvement of micro-lipid droplets and lipiddroplet-associated proteins in hormone-stimulated lipolysis in adipocytes2012
Author(s)
Hashimoto T, Segawa H, Okuno M, Kano H, Hamaguchi HO, Haraguchi T, Hiraoka Y, Hasui S, Yamaguchi T, Hirose F, Osumi T
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Journal Title
Journal of Cell Science
Volume: 125(24)
Issue: 24
Pages: 6127-6136
DOI
Related Report
Peer Reviewed
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