| Project/Area Number |
22700655
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Sports science
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Research Collaborator |
OHNO Hideki 杏林大学, 医学部, 教授 (00133819)
KIZAKI Takako 杏林大学, 医学部, 教授 (00322446)
OGASAWARA Jyunetsu 杏林大学, 医学部, 助教 (20415110)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 脂肪組織 / 運動トレーニング / 肥満 / 糖尿病 / リモデリング / 細胞外マトリックス / デルマトポンチン / インテグリンα1 / Dermatopontin / DNAアレイ |
|---|
| Research Abstract |
White adipose tissues(WAT) are remodeled due to exercise training(TR). The extracellular matrix(ECM), which encloses adipocytes, is thought to play an important role in remodeling of WAT. In the present study, therefore, the role of ECM in TR and obesity-specific remodeling of WAT was investigated. Expression of the gene for the dermatopontin(Dpt), which is one of the ECM, in WAT is higher in obese mice than in lean mice. TR definitely attenuated such obesity-induced Dpt gene expression in WAT. Moreover, TR enhanced expression of the ECM receptor integrinα1 gene in WAT. These results suggest that Dpt and integrinα1 are considered to be implicated in remodeling of WAT by TR.
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