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Roles of autophagy in slow-twitch skeletal muscle

Research Project

Project/Area Number 22700656
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Sports science
Research InstitutionJuntendo University

Principal Investigator

FURUYA Norihiko  順天堂大学, 医学部, 助教 (50401188)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsスポーツ性科学 / 廃用性筋萎縮 / オートファジー / Parkin / ミトコンドリア / 骨格筋 / 筋萎縮 / ノックアウトマウス / マイトファジー / ヒラメ筋 / Atg7ノックアウトマウス
Research Abstract

To evaluate the role of autophagy in skeletal muscle atrophy, we subjected skeletal muscle specific Atg7 deficient(Atg7 KO) mice to denervation, a model of skeletal muscle atrophy. Soleus muscle, a slow-twitch skeletal muscle, from Atg7 KO mice maintained muscle mass, while Soleus muscle from control mice, and first-twitch muscles from both wild type and Atg7 KO mice were atrophied. In the denervated Soleus muscles from Atg7 KO mice, the reduction of mitochondrial activity, the accumulation of oxidative stress and the accumulation of Parkin in mitochondria were observed. Parkin participates for mitochondrial quality control(Parkin mediated mitophagy). To confirm whether Parkin mediated mitophagy is involved in the restoration of denervation atrophy in Atg7 KO Soleus muscle, we subjected Parkin deficient(Parkin KO) mice to denervation. Like Atg7 KO Soleus, denervated Soleus muscles from Parkin KO mice maintained muscle mass. These results indicate that Parkin mediated mitophagy is involved in denervation atrophy in slow-twitch skeletal muscles.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (11 results)

All 2012 2011 2010 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (8 results) Remarks (1 results)

  • [Journal Article] Liver autophagy contributes to the maintenance of blood glucose and amino acid levels2011

    • Author(s)
      Ezaki, J., Matsumoto, N., Takeda-Ezaki, M., Komatsu, M., Takahashi, K., Hiraoka, Y., Taka, H., Fujimura, T., Takehana, K., Yoshida, M., Iwata, J., Tanida, I., Furuya, N., Zheng, D. M., Tada, N., Tanaka, K., Kominami, E., Ueno, T.
    • Journal Title

      Autophagy

      Volume: 7(7) Pages: 727-36

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Liver autophagy contributes to the maintenance of blood glucose and amino acid levels2011

    • Author(s)
      Ezaki, J., Matsumoto, N., Takeda-Ezaki, M., Komatsu, M., Takahashi, K., Hiraoka, Y., Taka, H., Fujimura, T., Takehana, K., Yoshida, M., Iwata, J., Tanida, I., Furuya, N., Zheng, D-m., Tada, N., Tanaka, K., Kominami, E., Ueno, T.
    • Journal Title

      Autophagy

      Volume: 7 Issue: 7 Pages: 727-736

    • DOI

      10.4161/auto.7.7.15371

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Gordon Research Conference "Autophagy in Stress, Development & Disease"2012

    • Author(s)
      Norihiko Furuya
    • Organizer
      Parkin mediated mitophagy is involved in slow-twitch skeletal muscle atrophy
    • Place of Presentation
      USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Parkin mediated mitophagy is involved in slow-twitch skeletal muscle atrophy2012

    • Author(s)
      Norihiko Furuya
    • Organizer
      Gordon Research Conference "Autophagy in Stress, Development & Disease"
    • Place of Presentation
      Ventura CA, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] 精神・神経疾患研究開発費23-5「筋シストロフィーおよひ関連疾患の診断・治療開発を目指した基盤研究」、筋萎縮におけるオートファジーの役割2011

    • Author(s)
      古屋徳彦
    • Organizer
      独立行政法人国立精神・神経医療研究センター
    • Place of Presentation
      JA共済ビルカンファレンスホール(東京)
    • Year and Date
      2011-12-06
    • Related Report
      2011 Final Research Report
  • [Presentation] 筋萎縮におけるオートファジーの役割2011

    • Author(s)
      古屋徳彦
    • Organizer
      独立行政法人国立精神・神経医療研究センター精神・神経疾患研究開発費23-5「筋ジストロフィーおよび関連疾患の診断・治療開発を目指した基盤研究」
    • Place of Presentation
      JA共済ビルカンファレンスホール(東京)
    • Year and Date
      2011-12-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] 骨格筋の萎縮とAutophagy2011

    • Author(s)
      古屋徳彦
    • Organizer
      第11回日本抗加齢医学会総会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2011-05-27
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 平成22年度特定領域「タンパク質分解」班会議2010

    • Author(s)
      古屋徳彦
    • Organizer
      骨格筋萎縮過程におけるオートファジーの役割
    • Place of Presentation
      シャトレーゼガトーキングダムサッポロ(札幌)
    • Year and Date
      2010-11-17
    • Related Report
      2011 Final Research Report
  • [Presentation] 骨格筋萎縮過程におけるオートファジーの役割2010

    • Author(s)
      古屋徳彦
    • Organizer
      平成22年度特定領域「タンパク質分解」班会議
    • Place of Presentation
      シャトレーゼガトーキングダムサッポロ(札幌)
    • Year and Date
      2010-11-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Autophagy is involved in slow skeletal muscle atrophy2010

    • Author(s)
      古屋徳彦
    • Organizer
      第62回日本細胞生物学会大会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2010-05-21
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.juntendo.ac.jp/graduate/laboratory/labo/seikagaku_saibo_seigyo/index.html

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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